Cystatin C level during retroperitoneoscopic procedures depending on pneumoperitoneum and retropneumoperitoneum modes
- Authors: Lobanov Y.S.1, Shapovalov K.G.1, Lobanov S.L.1, Tereshkov P.P.1, Lobanov L.S.1
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Affiliations:
- Chita State Medical Academy
- Issue: No 4 (2024)
- Pages: 65-68
- Section: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1728-2985/article/view/264894
- DOI: https://doi.org/10.18565/urology.2024.4.65-68
- ID: 264894
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Abstract
Aim. To study the dynamics of cystatin C in patients after procedures on retroperitoneal viscera using laparoscopic and retroperitoneal access.
Materials and methods. A prospective study of serum and urine cystostatin C levels in 162 patients with renal cysts using laparoscopic (n=83) and retroperitoneal access (n=79) was carried out. Patients were divided into four groups depending on the duration of the procedure and the gas level. For determination of cystatin C level in serum and urine, flow cytometry was performed using Human Kidney Function Panel 2 Mix and Match Subpanel (for Serum/Plasma Samples).
Results. A significant increase in the serum and urine level of cystatin C in groups 3 and 4 was seen on the 1st day after laparoscopic procedures in case of pneumoperitoneum pressure above 12 mm Hg., regardless of its duration. For retroperitoneoscopic procedures, similar changes were found only in group 4 with a gas pressure above 12 mm Hg and duration of the intervention of more than 30 minutes. By day 3, cystatin C levels returned to baseline values in all groups.
Conclusion. The most significant risk factor for acute kidney injury after laparoscopic and retroperitoneoscopic procedures is the gas pressure. The second most important factor is the duration of the intervention. Pneumoperitoneum has a greater effect on cystatin C levels compared to retropneumoperitoneum.
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##article.viewOnOriginalSite##About the authors
Yu. S. Lobanov
Chita State Medical Academy
Author for correspondence.
Email: yuriilobanov@mail.ru
ORCID iD: 0000-0002-9398-1447
PhD, Associate Professor at the Department of Faculty Surgery with a Course of Urology
Russian Federation, ChitaK. G. Shapovalov
Chita State Medical Academy
Email: shkg26@mail.ru
ORCID iD: 0000-0002-3485-5176
PhD, MD, Professor, Head of the Department of Anesthesiology and Resuscitation and Intensive Care
Russian Federation, ChitaS. L. Lobanov
Chita State Medical Academy
Email: slobanov15@mail.ru
ORCID iD: 0000-0003-1665-3754
PhD, MD, Professor, Head of the Department of Faculty Surgery with a Course of Urology
Russian Federation, ChitaP. P. Tereshkov
Chita State Medical Academy
Email: yuriilobanov@mail.ru
ORCID iD: 0000-0002-8601-3499
PhD, Head of the Laboratory of Experimental Biochemistry and Immunology
Russian Federation, ChitaL. S. Lobanov
Chita State Medical Academy
Email: slobanov15@mail.ru
ORCID iD: 0000-0001-6960-8370
PhD, Associate Professor at the Department of Faculty Surgery and Urology
Russian Federation, ChitaReferences
- Lombardo R., et al. Retroperitoneoscopy in urology: a systematic review. Minerva Urol Nefrol. 2019;71(1):9–16. doi: 10.23736/S0393-2249.18.03235-6.
- Terachi T., Yoshida O., Matsuda T., Orikasa S., Chiba Y., Takahashi K., Takeda M., Higashihara E., Murai M., Baba S., Fujita K., Suzuki K., Ohshima S., Ono Y., Kumazawa J., Naito S. Complications of laparoscopic and retroperitoneoscopic adrenalectomies in 370 cases in Japan: a multi-institutional study. Biomed Pharmacother. 2000;54(Suppl. 1):211s-214s. doi: 10.1016/s0753-3322(00)80047-5.
- Lobanov Yu.S., Shapovalov K.G., Lobanov S.L. Retroperitoneoscopic technology in retroperitoneal surgery. Urologiia. 2020;2:113–117. Russian (Лобанов Ю.С., Шаповалов К.Г., Лобанов С.Л. Ретроперитонеоскопическая технология в хирургии забрюшинного пространства. Урология. 2020;2:113–117).
- MacDonald C. et al. Predictors of complications following retroperitoneoscopic total and partial nephrectomy. J Pediatr Surg. 2018;7. pii: S0022-3468(18)30757-7. doi: 10.1016/j.jpedsurg.2018.10.097.
- Lobanov Yu.S., Ushakova O.A., Suturin M.V., Lobanov S.L., Shapovalov K.G. Reactions of the cardiovascular system during retroperitoneoscopic interventions on the organs of the retroperitoneal space. Urologiia. 2022;3:71–75. Russian (Лобанов Ю.С., Ушакова О.А., Сутурин М.В., Лобанов С.Л., Шаповалов К.Г. Реакции сердечно-сосудистой системы при ретроперитонеоскопических вмешательствах на органах забрюшинного пространства) Урология. 2022;3:71–75.
- Glavnova O.B., Yarmolinskaya M.I., Suslova S.V., Borovik N.V. Possibilities of using cystatin C in the diagnosis of various diseases. Zhurnal akusherstva i zhenskix boleznej. 2018;67(4):40–47. doi: 10.17816/jowd67440-47. Russian (Главнова О.Б., Ярмолинская М.И., Суслова С.В., Боровик Н.В. Возможности использования цистатина С в диагностике различных заболеваний. Журнал акушерства и женских болезней. 2018;67(4):40–47. doi: 10.17816/jowd67440-47)
- Tarasenko A.I., Pavlov V.N., Kabirov I.R., Alekseev A.V., Urmancev M.F. Cystatin C as a predictor of acute kidney injury after radical surgical treatment of patients with muscle-invasive bladder cancer. Research’n Practical Medicine Journal. 2021;8(2):75–82. https://doi.org/10.17709/2410-1893-2021-8-2-7. Russian (Тарасенко А.И., Павлов В.Н., Кабиров И.Р., Алексеев А.В., Урманцев М.Ф. Цистатин С как предиктор острого почечного повреждения после радикального хирургического лечения пациентов с мышечно-инвазивным раком мочевого пузыря. Research’n Practical Medicine Journal. 2021;8(2):75–82. https://doi.org/10.17709/2410-1893-2021-8-2-7).
- Luft F.C. Biomarkers and predicting acute kidney injury. Acta Physiol (Oxf). 2021;231(1):e13479. https://doi.org/10.1111/apha.13479
- Vel’kov V.V. Cystatin C and NGAL – the Markers of Preclinical Renal Dysfuction and Subclinical Acute Kidney Injury. Laboratory Service. 2015;4(2):38–43. https://doi.org/10.17116/labs20154238-43. Russian (Вельков В.В. Цистатин С и NGAL – маркеры преклинической ренальной дисфункции и субклинического острого повреждения почек. Лабораторная служба. 2015;4(2):38–43).
- Kellum J.A., Prowle J.R. Paradigms of acute kidney injury in the intensive care setting. Nat Rev Nephrol. 2018;14(4):217–230. https://doi.org/10.1038/nrneph.2017.184
- Parikh C.R., Mansour S.G. Perspective on Clinical Application of Biomarkers in AKI. J Am Soc Nephrol. 2017;28(6):1677–1685. https://doi.org/10.1681/ASN.2016101127
- Alekseev A.V., Gil`manov A.Zh., Gatiyatullina R.S., Rakipov I.G. Modern biomarkers of acute kidney injury. Prakticheskaya medicina. 2014;3(79):22–27. EDN SKAWUJ. Russian (Алексеев А.В., Гильманов А.Ж., Гатиятуллина Р.С., Ракипов И.Г. Современные биомаркеры острого повреждения почек. Практическая медицина. 2014;3(79):22–27. EDN SKAWUJ).
