Monitoring the migration and survival of mesenchymal stem cells in a critical bone defect model in dental implant sites: an experimental in vivo laboratory study

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BACKGROUND: Mesenchymal stem cells (MSCs) can migrate from the injection site to nearby injured areas, where they promote tissue repair. This expands the clinical applications of stem cells in regenerative medicine and improves treatment outcomes in patients with various injuries and diseases.

AIM: The work aimed to study the migration behavior of MSCs from the injection site to injured areas and evaluate their role in tissue repair during dental implantation.

METHODS: We labeled adipose-derived rat MSCs with a fluorescent dye and transplanted them into an area with a critical bone defect in a rat’s parietal bone.

RESULTS: Intravital dynamic imaging of MSCs in rats showed that the cells remained in the area of the bone defect and migrated to the lesion from distant injection sites during the 14-day follow-up.

CONCLUSION: Important evidence was obtained regarding the migration of MSCs and their potential for tissue regeneration in bone defects. MSCs can migrate from the injection site to nearby injured areas, where they promote tissue repair. This expands the clinical applications of stem cells in regenerative medicine and improves treatment outcomes in patients with various injuries and diseases.

作者简介

Irek Khafizov

Kazan (Volga Region) Federal University

编辑信件的主要联系方式.
Email: khafizovirek@mail.ru
ORCID iD: 0000-0003-4077-2788
SPIN 代码: 9973-5280

MD, Cand. Sci. (Medicine), Associate Professor

俄罗斯联邦, Kazan

Fanilya Khafizova

Kazan (Volga Region) Federal University

Email: fanilyakhafizova@mail.ru
ORCID iD: 0000-0002-1262-5513
SPIN 代码: 5613-7720

MD, Cand. Sci. (Medicine), Associate Professor

俄罗斯联邦, Kazan

Elena Zakirova

Kazan (Volga Region) Federal University

Email: lenahamzina@yandex.ru
ORCID iD: 0000-0001-6750-640X
SPIN 代码: 4022-8554

Cand. Sci. (Biology)

俄罗斯联邦, Kazan

Margarita Zhuravleva

Kazan (Volga Region) Federal University

Email: MNZhuravleva@kpfu.ru
ORCID iD: 0000-0001-8592-5325
SPIN 代码: 8306-5622

Cand. Sci. (Biology)

俄罗斯联邦, Kazan

Elnara Biktagirova

Kazan (Volga Region) Federal University

Email: EMBiktagirova@kpfu.ru
ORCID iD: 0000-0003-1455-5544
SPIN 代码: 6575-0764

Cand. Sci. (Biology)

俄罗斯联邦, Kazan

Albert Rizvanov

Kazan (Volga Region) Federal University; Tatarstan Academy of Sciences

Email: Albert.Rizvanov@kpfu.ru
ORCID iD: 0000-0002-9427-5739
SPIN 代码: 7031-5996

Dr. Sci. (Biology), Professor

俄罗斯联邦, Kazan; Kazan

参考

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