THE MICROBIAL LANDSCAPE OF THE ORAL CAVITY IN THE PATIENTS PRESENTING WITH GNATHIC DEFECTS AND LOCAL ANTIBIOTIC THERAPY

The objective of the present work was to estimate the antibiotic and anti-inflammatory effects of "Klyuchi ’ mineral water in the patients presenting with the defects of upper and lower jaws. The clinical and microbiological examination involved a total of 40 subjects including 15 patients with the defects of the upper and lower jaws whose rehabilitative treatment was carried out with the use of the mineral water for irrigation and rinsing of the oral cavity. Ten patients with gnathic defects who used distilled water for rinsing and irrigation constituted the control group. It was shown that the treatment with mineral water resulted in a decrease of the number of CF strains of pathogenic and opportunistic microorganisms and a reduction of their virulence potential. Specifically, more than half of them did not show hemolytic properties and almost all lost the phospholipase activity. Importantly, the microbial associations in 13 patients included fungi of the genus Candida, mostfrequently in the diagnostically important titers (≥ 104 CFU / ml). The irrigation of the oral cavity with mineral water allowed their complete elimination to be achieved. The results of the study have demonstrated the high balneotherapeutic efficacy of the "Klyuchi" drinking mineral water which gives ground to recommend its application for the treatment and prevention of oral cavity dysbacteriosis in the patients presenting with the defects of both jaws and after osteoplastic interventions on the mandible.

gnathic defects, correction of microenvironment, mineral water