Molecular-genetic testing in preoperative diagnosis and choice of surgical tactics in patients with thyroid neoplasms
- 作者: Romashchenko P.1, Maistrenko N.1, Ivanov A.1, Krivolapov D.1, Simonova M.1
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隶属关系:
- Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
- 期: 卷 23, 编号 4 (2021)
- 页面: 153-160
- 栏目: Clinical trials
- URL: https://journals.rcsi.science/1682-7392/article/view/79445
- DOI: https://doi.org/10.17816/brmma79445
- ID: 79445
如何引用文章
详细
The high frequency of the detection of follicular thyroid tumors requires the development of the most effective new methods for their differential diagnosis to early verification of well-differentiated cancer, reduce the number of unjustified surgical interventions, select their rational volume, and improve the treatment results. The use of molecular genetic research methods in preoperative diagnostics and the choice of surgical tactics in patients with the thyroid neoplasms was substantiated. To optimize the algorithm of diagnosis and treatment, a retrospective analysis of the results of examination and surgical treatment of 100 patients with the thyroid neoplasms was carried out, the diagnosis of which was supplemented by the determination of molecular genetic markers in the cellular material of the puncture fine-needle biopsy using a flow fluor-cytometry and polymerase chain reaction. The diagnostic significance of the preoperative determination of the tumor marker Galectin-3, the V600E mutation of the BRAF gene in the puncture material in the detection of thyroid cancer and the choice of the rational surgical tactics was assessed. The prognostic value of the sodium iodide symporter in the development of a thyroid cancer resistance to postoperative radioactive iodine therapy has been established, which makes it possible to substantiate the need to expand the scope of the surgical intervention. The use of an optimized diagnostic and treatment algorithm, considering a new molecular genetic research methods in this category of the patients, contributes to the choice of individualized surgical tactics, depending on the nature of the pathological process.
作者简介
Pavel Romashchenko
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
Email: romashchenko@rambler.ru
ORCID iD: 0000-0001-8918-1730
SPIN 代码: 3850-1792
doctor of medical sciences, professor
俄罗斯联邦, Saint PetersburgNicolay Maistrenko
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
Email: nik.m.47@mail.ru
ORCID iD: 0000-0002-1405-7660
SPIN 代码: 2571-9603
doctor of medical sciences, professor
俄罗斯联邦, Saint PetersburgAndrey Ivanov
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
Email: iamvma@mail.ru
ORCID iD: 0000-0002-8899-7524
SPIN 代码: 6971-1744
doctor of medical sciences, professor
俄罗斯联邦, Saint PetersburgDenis Krivolapov
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
Email: d.s.krivolapov@yandex.ru
ORCID iD: 0000-0002-9499-2164
SPIN 代码: 2195-5001
candidate of medical Sciences
俄罗斯联邦, Saint PetersburgMaria Simonova
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
编辑信件的主要联系方式.
Email: mariasimonova62@gmail.co
ORCID iD: 0000-0002-8359-1875
SPIN 代码: 6004-1995
clinical resident
俄罗斯联邦, Saint Petersburg参考
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