Investigation of specific activity and harmlessness of simultaneous administration of vaccines in complex immunoprophylaxis of dangerous infectious diseases

Experimental study of specific activity and harmlessness of simultaneous application of five vaccines (abdominal, Zonne dysentery, viral hepatitis A, meningococcal and live yellow fever vaccine) in complex immunoprophylaxis of dangerous infectious diseases was carried out. It has been found that the simultaneous administration of these vaccines is safe and has high immunogenicity and protective efficacy for each infection not inferior to, and in some cases superior to, vaccines administered separately. In particular, the immunogenicity of vaccines against typhoid fever and viral hepatitis A administered jointly was four times higher than with their separate administration, which may indicate the presence of a certain adjuvant effect on the part of other vaccines, as well as the absence of antagonism in their joint use. It was revealed that complex vaccinations do not negatively affect the functional state of cells involved in the initial stage of immunogenesis. The absence of a negative effect of complex vaccinations on the components of nonspecific resistance of the body was almost completely confirmed in the conditions of infection of immunized animals with influenza virus, that is, in modeling heterologous infection. In addition, immunization with a complex of vaccines does not lead to allergic animals, which is confirmed by the absence of any manifestations of allergic reactions or anaphylactic activity.