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Glucagon-like peptid-1 in obese and diabetic patients after bariatric interventions
- 作者: Volkova A.R.1, Semikova G.V.1, Mozgunova V.S.1, Maltseva M.N.1, Bondarenko V.L.1, Katysheva N.S.1
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隶属关系:
- Pavlov First Saint Petersburg State Medical University
- 期: 卷 23, 编号 1 (2021)
- 页面: 89-94
- 栏目: Clinical trials
- URL: https://journals.rcsi.science/1682-7392/article/view/57488
- DOI: https://doi.org/10.17816/brmma57488
- ID: 57488
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详细
The relationship between the level of glucagon-like peptide-1 and repeated weight gain was evaluated in 31 patients suffering from grade II–III obesity and type 2 diabetes mellitus after bariatric interventions for 3 years. It was found that the level of stimulated glucagon-like peptide-1 significantly increased by the third day after sleeve gastroplasty and gastroschunt compared to the initial parameters (p = 0.001 for obese patients; p = 0.000 for obese patients and diabetes mellitus). In the plateau phase (body weight retention) after bariatric intervention, the level of stimulated glucagon-like peptide-1 in obese patients and patients suffering from obesity in combination with diabetes mellitus did not significantly differ from the indicators of healthy individuals. There was no association between the level of glucagon-like peptide-1 and repeated weight gain. This may be due to the limited contribution of glucagon-like peptide-1 to body weight dynamics after bariatric interventions and the predominance of patient compliance. Thus, the level of stimulated glucagon-like peptide-1 at baseline, on the third day and in the plateau phase after bariatric intervention was not associated with the value of repeated weight gain.
作者简介
Anna Volkova
Pavlov First Saint Petersburg State Medical University
编辑信件的主要联系方式.
Email: volkovaa@mail.ru
ORCID iD: 0000-0002-5189-9365
Doctor of Science in Medical Sciences, Professor
俄罗斯联邦, L'va Tolstogo str. 6-8 Saint Petersburg, 197022Galina Semikova
Pavlov First Saint Petersburg State Medical University
Email: semikovagv@yandwx.ru
ORCID iD: 0000-0003-0791-4705
SPIN 代码: 4534-0974
assistant of faculty therapy
俄罗斯联邦, L'va Tolstogo str. 6-8 Saint Petersburg, 197022Valentina Mozgunova
Pavlov First Saint Petersburg State Medical University
Email: sidelnikovavalya@mail.ru
ORCID iD: 0000-0002-0841-3438
assistant of faculty therapy
俄罗斯联邦, L'va Tolstogo str. 6-8 Saint Petersburg, 197022Margarita Maltseva
Pavlov First Saint Petersburg State Medical University
Email: m-maltseva@mail.ru
Head of the Department of Pharmacokinetics and Hormonal Diagnostics
俄罗斯联邦, L'va Tolstogo str. 6-8 Saint Petersburg, 197022Vladimir Bondarenko
Pavlov First Saint Petersburg State Medical University
Email: m-maltseva@mail.ru
clinical laboratory diagnostics doctor
俄罗斯联邦, L'va Tolstogo str. 6-8Saint Petersburg, 197022Nadezhda Katysheva
Pavlov First Saint Petersburg State Medical University
Email: m-maltseva@mail.ru
clinical laboratory diagnostics doctor
俄罗斯联邦, 6/8, Lva Tolstogo street, St. Petersburg, 197089参考
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