病理组织发生中的端粒细胞
- 作者: Odintsova I.A.1, Berezovskaya T.I.1, Slutskaya D.R.1
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隶属关系:
- Kirov Military Medical Academy
- 期: 卷 26, 编号 3 (2024)
- 页面: 437-446
- 栏目: Review
- URL: https://journals.rcsi.science/1682-7392/article/view/264265
- DOI: https://doi.org/10.17816/brmma626979
- ID: 264265
如何引用文章
详细
根据对科学电子图书馆eLibrary.Ru、俄罗斯国家图书馆和PubMed电子数据库中包含的科学材料的分析,研究了端细胞的超显微结构及其在各种器官病理学中的作用。研究表明,端粒细胞是中胚层形成的细胞,是多裂殖疏松结缔组织的一部分。它们的特征是存在被称为 “端突”的长形突起,这些突起在许多器官中形成了一个网络,将它们与周围的组织元素连接起来。它们也是真皮和肌肉再生的一部分,并存在于一些组织干细胞和祖细胞附近。据推 测,这种排列可能与参与局部新陈代谢过程有关。在组织学制片上检测端粒细胞的主要方法是电子显微镜;除此之外,还建议使用免疫组化染色技术和半薄切片的光学显微镜。端粒是新陈代谢过程的积极调节者,也是循环、呼吸、排泄等器官病理组织发生的参与者。文中举例说明了与端粒细胞有关的疾病和病理状况。大量科学出版物致力于研究端粒细胞在血液循环系统病理学中的作用。这些细胞主要分布在心肌内的结缔组织中,位于毛细血管之间,靠近神经末梢。细胞的端粒通常指向血管网络和神经干。研究人员认为,心肌内的端粒细胞是细胞间信号传递的关键调节器,对心脏功能及其组织结构的反应性变化有重要影响。我们评估了在正常生理条件下和病理过程中进一步研究和阐明这种细胞异构体的定位和形态功能特征的前景。对端粒细胞功能的进一步阐明和澄清将优化病理过程矫正方法的开发, 包括使用细胞疗法。
作者简介
Irina A. Odintsova
Kirov Military Medical Academy
Email: odintsova-irina@mail.ru
ORCID iD: 0000-0002-0143-7402
SPIN 代码: 1523-8394
Scopus 作者 ID: 6603745712
MD, Dr. Sci. (Med.), professor
俄罗斯联邦, Saint PetersburgTatyana I. Berezovskaya
Kirov Military Medical Academy
编辑信件的主要联系方式.
Email: vmeda-nio@mil.ru
ORCID iD: 0009-0009-1591-9152
SPIN 代码: 2508-7042
lecturer
俄罗斯联邦, Saint PetersburgDina R. Slutskaya
Kirov Military Medical Academy
Email: dina_hanieva@mail.ru
ORCID iD: 0000-0003-3910-2621
SPIN 代码: 2546-9393
Scopus 作者 ID: 57222070377
Researcher ID: 882535
MD, Cand. Sci. (Biol.), associate professor
俄罗斯联邦, Saint Petersburg参考
- Klishov AA. Histogenesis and tissue regeneration. Leningrad: Medicine; 1984. 232 p. (In Russ.)
- Danilov RK. Wound process: histogenetic basis. Saint Petersburg: MMA; 2007. 380 p. (In Russ.)
- Gololobov VG. Selected works on bone tissue regeneration and the history of histology. Anniversary collection. Moscow: Practical Medicine; 2023. 271 p. (In Russ.)
- Odintsova IA, Slutskaya DR, Berezovskaya TI. Telocytes: localization, structure, functions and significance in pathology. Genes & Cells. 2022;17(1):6–12. (In Russ.) EDN: UIXBAQ doi: 10/23868/202205001
- Chekmareva IA, Paklina OV, Deev RV, et al. Structural and functional changes of telocytes in various pathological processes. In: Questions of morphology of the XXI century. Vol. 7. Saint Petersburg: DEAN; 2023. P. 339–343. (In Russ.)
- Aleksandrovych V, Pasternak A, Basta P, et al. Telocytes: facts, speculations and myths. Folia Med Cracov. 2017;57(1):5–22.
- Díaz-Flores L, Gutiérrez R, Díaz-Flores L Jr, et al. Behaviour of telocytes during physiopathological activation. Semin Cell Dev Biol. 2016;55:50–61. doi: 10.1016/j.semcdb.2016.01.035
- Varga I, Polák Š, Klein M, et al. Recently discovered interstitial cell population of telocytes: distinguishing facts from fiction regarding their role in the pathogenesis of diverse diseases called "telocytopathies". Medicina (Kaunas). 2019;55(2):56. doi: 10.3390/medicina55020056
- Zheng Y, Bai C, Wang X. Telocyte morphologies and potential roles in diseases. J Cell Physiol. 2012;227(6):2311–2317. doi: 10.1002/jcp.23022
- Berezovskaya T.I., Odintsova I.A., Rusakova S.E. Telocytes in regeneration and embryonic histogenesis of connective tissue. In: International Scientific and Practical Conference “Actual issues of fundamental and clinical morphology”. Tver; 2022. P. 73–76. (In Russ.)
- Rosa I, Marini M, Manetti M. Telocytes: an emerging component of stem cell niche microenvironment. J Histochem Cytochem. 2021;69(12):795–818. doi: 10.1369/00221554211025489
- Cretoiu D, Vannucchi MG, Bei Y, et al. Telocytes: new connecting devices in the stromal space of organs. In: Innovations in cell research and therapy. London: InthechOpen; 2020: 69–94. doi: 10.5772/intechopen.89383.
- Klochkov ND. Histion as an elementary morphofunctional unit. Morfologia. 1997;5:87–88. (In Russ.)
- Danilov RK, Odintsova IA, Grigoryan BA, et al. Histion structure of the tissue during regenerative histogenesis. Morfologia. 2008;133(2):38–39. EDN: JUTQSH
- Liskova YV, Stadnikov AA, Salikova SP. The role of telocytes in myocardial remodeling and the development of cardiovascular complications in patients with chronic heart failure after coronary artery bypass grafting. Kardiologiia. 2018;58(S8):29–37. EDN: UWAOSB doi: 10.18087/cardio.2455
- Varga I, Danisovic L, Kyselovic J, et al. The functional morphology and role of cardiac telocytes in myocardium regeneration. Can J Physiol Pharmacol. 2016;94(11):1117–1121. doi: 10.1139/cjpp-2016-0052
- Podzolkov VI, Tarzimanova AI, Frolova AS. Telocytes and atrial fibrillation: from basic research to clinical practice. Rational Pharmacotherapy in Cardiology. 2020;16(4):590–594. EDN: SPQIAF doi: 10.20996/1819-6446-2020-08-18
- Popescu LM, Faussone-Pellegrini MS. Telocytes — A case of serendipity: the winding way from Interstitial Cells of Cajal (ICC), via Interstitial Cajal-Like Cells (ICLC) to telocytes. J Cell Mol Med. 2010;14(4):729–740. doi: 10.1111/j.1582-4934.2010.01059.x
- Rusu MC, Hostiuc S. Critical review: cardiac telocytes vs cardiac lymphatic endothelial cells. Ann Anat. 2019;222:40–54. doi: 10.1016/j.aanat.2018.10.011
- Zhao B, Chen S, Liu J, et al. Cardiac telocytes were decreased during myocardial infarction and their therapeutic effects for ischaemic heart in rat. J Cell Mol Med. 2013;17(1):123–133. doi: 10.1111/j.1582-4934.2012.01655.x
- Ja KPMM, Miao Q, Tee NGZ, et al. iPSC-derived human cardiac progenitor cells improve ventricular remodelling via angiogenesis and interstitial networking of infarcted myocardium. J Cell Mol Med. 2016;20(2):323–332. doi: 10.1111/jcmm.12725
- Xu Y, Tian H, Qiao G, Zheng W. Telocytes in the atherosclerotic carotid artery: immunofluorescence and tem evidence. Acta Histochem. 2021;123(2):151681. doi: 10.1016/j.acthis.2021.151681
- Sukhacheva TV, Serov RA, Nizyaeva NV, et al. Telocytes in the myocardium of children with congenital heart disease tetralogy of Fallot. Bull Exp Biol Med. 2020;169(1):137–146. doi: 10.1007/s10517-020-04840-7
- Mitrofanova LB, Hazratov AO, Gurshchenkov AV, et al. Morphological examination of telocytes in the left atrium in patients with long-term persistent atrial fibrillation. Russian Journal of Cardiology. 2019;24(7):53–62. EDN: GCZMQT doi: 10.15829/1560-4071-2019-7-53-62
- Mitrofanova LB, Hazratov AO, Krasnoshlyk PV, et al. Morphological study of telocytes in different parts of the normal adult human brain. Medline.ru. 2018;19(1):281–306. EDN: YLQMXB
- Salvador E, Kessler AF, Hoermann J, et al. Tumor treating fields effects on the blood-brain barrier in vitro and in vivo. J Clin Oncol. 2020;38(Suppl. 15):2551. doi: 10.1200/jco.2020.38.15_suppl.2551
- Cucu IL, Nicolescu MI. A synopsis of signaling crosstalk of pericytes and endothelial cells in salivary gland. Dent J (Basel). 2021;9(12):144. doi: 10.3390/dj9120144
- Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science. 2003;299(5607):708–710. doi: 10.1126/science.1079666
- Liu Y, Fan Y, Wu S. Developments in research on interstitial Сajal-like cells in the biliary tract. Expert Rev Gastroenterol Hepatol. 2021;15(2):159–164. doi: 10.1080/17474124.2021.1823214
- Zheng Y, Bai C, Wang X. Potential significance of telocytes in the pathogenesis of lung diseases. Expert Rev Respir Med. 2012;6(1): 45–49. doi: 10.1586/ers.11.91
- Khlopin N.G. General biological and experimental bases of histology. Leningrad: Academy of Sciences of the USSR; 1946. 491 p. (In Russ.)
- Zavarzin AA. Sketches of evolutionary histology of blood and connective tissue. Мoscow: Medgiz; 1945. 291 p. (In Russ.)
- Gevaert T, De Vos R, Everaerts W, et al. Characterization of upper lamina propria interstitial cells in bladders from patients with neurogenic detrusor over activity and bladder pain syndrome. J Cell Mol Med. 2011;15(12):2586–2593. doi: 10.1111/j.1582-4934.2011.01262.x
- Cretoiu SM, Cretoiu D, Popescu LM. Human myometrium – the ultrastructural 3D network of telocytes. J Cell Mol Med. 2012;16(11):2844–2849. doi: 10.1111/j.1582-4934.2012.01651.x
- Aleksandrovych V, Białas M, Pasternak A, et al. Identification of uterine telocytes and their architecture in leiomyoma. Folia Med Cracov. 2018;58(3):89–102. doi: 10.24425/fmc.2018.125075
- Chekmareva IA, Paklina OV, Skripchenko DV. Telocytes (interstitial cajal like cells) of the fallopian tubes in acute and chronic salpingitis. Genes & Cells. 2021;16(2):39–46. EDN: DKVLWS doi: 10.23868/202107004
- Zhang F-L, Huang Y-L, Zhou X-Y, et al. Telocytes enhanced in vitro decidualization and mesenchymal-epithelial transition in endometrial stromal cells via Wnt/β-catenin signaling pathway. Am J Transl Res. 2020;12(8):4384–4396.
- Mihalcea CE, Moroşanu A-M, Murăraşu D, et al. Analysis of TP53 gene and particular infrastructural alterations in invasive ductal mammary carcinoma. Rom J Morphol Embryol. 2020;61(2):441–447. doi: 10.47162/RJME.61.2.13
- Klein M, Lapides L, Fecmanova D, Varga I. Novel cellular entities and their role in the etiopathogenesis of female idiopathic infertility – a review article. Clin Exp Obstet Gynecol. 2021;48(3):461–465. doi: 10.31083/j.ceog.2021.03.2395
- Abu-Dief EE, Elsayed HM, Atia EW, et al. Modulation of telocytes in women with preeclampsia: A prospective comparative study. J Microsc Ultrastruct. 2021;9(4):158–163. doi: 10.4103/JMAU.JMAU_52_20
- Mou Y, Wang Y, Li J, et al. Immunohistochemical characterization and functional identification of mammary gland telocytes in the self-assembly of reconstituted breast cancer tissue in vitro. J Cell Mol Med. 2013;17(1):65–75. doi: 10.1111/j.1582-4934.2012.01646.x
- Sanches BDA, Maldarine JS, Felisbino SL, et al. Stromal cell interplay in prostate development, physiology, and pathological conditions. Prostate. 2021;81(13):926–937. doi: 10.1002/pros.24196
- Cismasiu VB, Popescu LM. Telocytes transfer extracellular vesicles loaded with micro RNAs to stem cells. J Cell Mol Med. 2015;19(2):351–358. doi: 10.1111/jcmm.12529
- Chekmareva IA, Deev RV, Chernova ON, et al. Cells corresponding to telocites have been detected in pathologically altered skeletal muscle. Genes & Cells. 2022;17(1):38–41. EDN: LZTEWI doi: 10.23868/202205007
- Chekmareva IA, Paklina OV. Telocytes (Interstitial Cajal-like cells) in cutaneous wound regeneration. Genes & Cells. 2022;17(3):252. (In Russ.) EDN: GFFCZI