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Prospects for the development of technical devices and dosage forms for the use of medical protection.
- Authors: Ivanov IM1, Chepur SV1, Nikiforov AS1, Yudin MA1, Averina AL1
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Affiliations:
- State research testing Institute of military medicine of the Ministry of defense of the Russian Federation
- Issue: Vol 21, No 4 (2019)
- Pages: 47-53
- Section: Articles
- URL: https://journals.rcsi.science/1682-7392/article/view/20661
- DOI: https://doi.org/10.17816/brmma20661
- ID: 20661
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Abstract
The article assesses the current level of technical devices and dosage forms intended for the use of medical protective equipment, discusses global trends and prospects for their short-term and medium-term development. Considered foreign samples autoinjectors, portable inhalers, patch pump, nasal, transdermal and buccal forms. Presents indicators of the effectiveness of various dosage forms, their advantages and disadvantages, discusses ways to overcome the latter in the provision of medical care in the prehospital stages and in transporting the wounded and affected. When assessing the possibility of using medical protection in various technical devices or dosage forms, it is necessary to consider the characteristics of their manufacturability and the readiness of the domestic production base for mass production and state registration as medicines or medical products. It was concluded that in the short term for the development of domestic medical remedies it is advisable to introduce inhaled and intranasal forms of drugs for use in the prehospital medical care.
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##article.viewOnOriginalSite##About the authors
I M Ivanov
State research testing Institute of military medicine of the Ministry of defense of the Russian Federation
Email: gniiivm_15@mil.ru
кандидат медицинских наук, майор медицинской службы Saint-Petersburg
S V Chepur
State research testing Institute of military medicine of the Ministry of defense of the Russian Federationпрофессор, полковник медицинской службы Saint-Petersburg
A S Nikiforov
State research testing Institute of military medicine of the Ministry of defense of the Russian Federationдоктор биологических наук Saint-Petersburg
M A Yudin
State research testing Institute of military medicine of the Ministry of defense of the Russian Federationдоктор медицинских наук, подполковник медицинской службы Saint-Petersburg
A L Averina
State research testing Institute of military medicine of the Ministry of defense of the Russian FederationSaint-Petersburg
References
- Шустиков В.М. Исследование по разработке аэрозольного метода иммунизации людей против сибирской язвы: Автореф. диc. ….. д-ра мед. наук. - М., 1992.
- Aldington D, Jagdish S. The fentanyl «lozenge» story: from books to battlefield // J. R. Army Med. Corps. - 2014. - Vol. 160, N 2. - P. 102-104.
- Blankenstein T.N., Gibson L.M., Claydon M.A. Is intramuscular morphine satisfying frontline medical personnels’ requirement for battlefield analgesia in Helmand Province, Afghanistan? A questionnaire study // Br. J. Pain. - 2015. - Vol. 9, N 2. - P. 115-121.
- Corcoran T.E., Venkataramanan R., Hoffman R.M. et al. Systemic Delivery of Atropine Sulfate by the MicroDose Dry-Powder Inhaler // J. Aerosol. Med. Pulm. Drug Deliv. - 2013. - Vol. 26, N 1. - P. 46-55.
- Gil A., Nachum Z. A comparison of cinnarizine and transdermal scopolamine for the prevention of seasickness in naval crew: a double-blind, randomized, crossover study // Clin. Neuropharmacol. - 2012. - Vol. 35, N 1. - P. 37-39.
- Grеmy O., Tsapis N., Chau Q. et al. Preferential decorporation of americium by pulmonary administration of DTPA dry powder after inhalation of aged PuO(2) containing americium in rats // Radiat. Res. - 2010. - Vol. 174, N 5. - P. 217-223.
- Loftsson T., Gudmundsdуttir H., Sigurjуnsdуttir J.F. et al. Cyclodextrin solubilization of benzodiazepines: formulation of midazolam nasal spray // Int. J. Pharm. - 2001. - Vol. 212, N 1. - P. 29-40.
- Meridian Medical Technologies Official Site - Products. URL: http://www.meridian meds.com/products (дата обращения: 16.02.2019).
- MicroDose completes atropine inhaler Phase I study on nerve agent poisoning. URL: https://www.news-medical.net/ (дата обращения: 16.02.2019).
- Military Advanced Regional Anesthesia and Analgesia Handbook. - Houston: Borden Institute, Walter Reed Army Medical Center. - 2008. - P. 154.
- Multiservice Tactics, Techniques and Procedures for Treatment of Chemical Agent Casualties and Conventional Military Chemical Injuries. URL: https://fas.org/irp/doddir/army/atp4-02-85.pdf (дата обращения: 16.02.2019).
- Peron N., Le Guen P., Andrieu V. et al. Inhalation therapy: inhaled generics, inhaled antidotes, the future of anti-infectives and the indications of inhaled pentamidine // Rev. Mal. Respir. - 2013. - Vol. 30. - P. 832-842.
- Sanchez J.L., Cooper M.J., Myers C.A. et al. Respiratory Infections in the US Military: Recent Experience and Control // Clin. Microbiol. Rev. - 2015. - Vol. 28. - P. 743-800.
- Schrier L., Zuiker R., Merkus F.W. et al. Pharmacokinetics and pharmacodynamics of a new highly concentrated intranasal midazolam formulation for conscious sedation // Br. J. Clin. Pharmacol. - 2017. - Vol. 83, N 4. - P. 721-731.
- Schug S.A., Ting S. Fentanyl Formulations in the Management of Pain: An Update // Drugs. - 2017. - Vol. 77, N 7. - P. 747-763.
- Tonnis W., Kersten G., Frijlink H. et al. Pulmonary Vaccine Delivery: A Realistic Approach? // Journal of aerosol medicine and pulmonary drug delivery. - 2012. - Vol. 25, N 5. - P. 249-260.
- Wermeling D.P. Intranasal delivery of antiepileptic medications for treatment of seizures // Neurotherapeutics. - 2009. - Vol. 6. - P. 50-51.
- Ziemba R. Use of individual auto-injector kits «IZAS-05» on the contemporary battlefield // Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. - 2012. - Vol. 18, N 1. - P. SR1-SR8.
