Informativity of the method of correlation adaptometry for assessing the severity of the corrective effect of combined use therapeutic physical factors on the example of metabolic syndrome

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BACKGROUND: Evaluation of the effectiveness of the use of therapeutic physical factors using the method of correlation adaptometry is based on the effect of increasing the number of severity of correlation dependencies between the parameters characterizing the functional state of the body under the action of a stressor.

AIM: Evaluation of the effectiveness of the combined use of transcranial magnetotherapy and a pulsed low-frequency electrostatic field in patients with metabolic syndrome using the method of correlation adaptometry.

MATERIALS AND METHODS: The study involved 100 patients with a diagnosis of metabolic syndrome established in accordance with clinical guidelines. All patients were divided into four groups of 25 by simple fixed randomization. Patients in the control group received a placebo effect (imitation of physiotherapeutic effects with the device turned off) for 10 days of observation, in comparison group 1 ― exposure to a low-frequency electrostatic field, in comparison group 2 ― transcranial magnetotherapy with a traveling magnetic field, in the main group ― exposure to a pulsed electrostatic field in combination with transcranial magnetotherapy. The objectification of the effects of physiotherapy (evaluation of functional, biochemical and hormonal parameters) was based on a two-stage examination (before and after a course of treatment).

RESULTS: Correlation adaptometry was based on the results of correlation analysis using a correlation matrix of variables characterizing the condition of patients after course correction. For each of the four groups of patients, 28 correlation coefficients were determined. For each group, 378 correlation coefficients were calculated, presented as the weight of the correlation graph. Additionally, the indicator of the average adaptive correlation was calculated. It is shown that the use of therapeutic physical factors is accompanied by a decrease in the weight of the correlation graph, which indicates the severity of the clinical effect due to the sanogenetic action of physiofactors. The most pronounced decrease was noted in the group of combined physiotherapy. Correlation analysis between the parameters of the average adaptive correlation and the integral coefficient of therapy efficiency showed that there is a strong, negative significant relationship between the HOMA insulin resistance index and the Quetelet index, chosen as the most informative variables.

CONCLUSION: It is concluded that the method of correlation adaptometry is highly informative in assessing the effectiveness of using a pulsed low-frequency electrostatic field, transcranial magnetotherapy and their combined effects in patients with metabolic syndrome. A decrease in the indicator of the average adaptive correlation indicates an increase in the functional reserves of the system, the patterns of which are changes in certain estimated parameters that are not related to each other.

作者简介

Andrey Benkov

Limited Liability Company "Med TeKo"

Email: a.benkov@medteco.ru
ORCID iD: 0000-0003-4074-7208
俄罗斯联邦, Moscow

Sergey Nagornev

Central State Medical Academy of Department of Presidential Affairs

编辑信件的主要联系方式.
Email: drnag@mail.ru
ORCID iD: 0000-0002-1190-1440
SPIN 代码: 2099-3854

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, 19/1A Marshal Timoshenko street, 121359 Moscow

Valery Frolkov

Centre for Strategic Planning and Management of Biomedical Health Risks

Email: fvk49@mail.ru
ORCID iD: 0000-0002-1277-5183
SPIN 代码: 3183-0883

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, Moscow

Dmitry Edelev

Scientific and Educational Center of Applied Medicine and Food Safety "Biomed" Lomonosov Moscow State University

Email: d.a.edelev@vk.com
ORCID iD: 0000-0002-5863-2284
SPIN 代码: 8365-9867
俄罗斯联邦, Moscow

Olga Korlyakova

The First Sechenov Moscow State Medical University (Sechenov University)

Email: ovk_mma@mail.ru
ORCID iD: 0000-0002-2650-267X
SPIN 代码: 8468-2386
俄罗斯联邦, Moscow

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2. Fig. 1. The values of the average adaptive correlation during correlation adaptometry for various schemes of correction of manifestations of metabolic syndrome. ИНЭСП ― pulsed low-frequency electrostatic field; ТМТ ― transcranial magnetotherapy.

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3. Fig. 2. Values of the integral coefficient of therapy effectiveness in various treatment regimens of metabolic syndrome. ИНЭСП ― pulsed low-frequency electrostatic field; ТМТ ― transcranial magnetotherapy.

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