Estimation of Metabolism of Catecholamines in Peripheral Organs As an Indicator of Their Desympathization under the Influence of Neurotoxins
- Autores: Safandeev V.V.1, Kolacheva A.A.1, Ugrumov M.V.1
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Afiliações:
- Koltzov Institute of Developmental Biology, Russian Academy of Sciences
- Edição: Volume 486, Nº 1 (2019)
- Páginas: 171-174
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212990
- DOI: https://doi.org/10.1134/S1607672919030037
- ID: 212990
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Resumo
Under conditions of the experimental model of Parkinson’s disease at the preclinical (early) and clinical stage—injection of mice with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 5 and 10 weeks—the toxic effects of MPTP was evaluated (the content of catecholamines and their metabolites in the heart, which receives the most extensive sympathetic innervation, was determined). The obtained data indicated the beginning of desympathization of the heart at the preclinical stage of PD and its progression at the clinical stage of the disease.
Sobre autores
V. Safandeev
Koltzov Institute of Developmental Biology,Russian Academy of Sciences
Autor responsável pela correspondência
Email: visa.doc@mail.ru
Rússia, Moscow, 119334
A. Kolacheva
Koltzov Institute of Developmental Biology,Russian Academy of Sciences
Email: visa.doc@mail.ru
Rússia, Moscow, 119334
M. Ugrumov
Koltzov Institute of Developmental Biology,Russian Academy of Sciences
Email: visa.doc@mail.ru
Rússia, Moscow, 119334
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