电邮这篇文章 The metabolic changes in tumor-associated macrophages during cancer grow in mice with Ehrlich ascites carcinoma
- 作者: Inzhevatkin E.V.1, Savchenko A.A.2
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隶属关系:
- Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the RAS
- Research Institute for Medical Problems in the North Division of Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the RAS”
- 期: 卷 475, 编号 1 (2017)
- 页面: 277-279
- 栏目: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211953
- DOI: https://doi.org/10.1134/S1607672917040081
- ID: 211953
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详细
In this work, we investigated the activity of the key NAD(P)-dependent dehydrogenases associated with macrophage tumors in mice with Ehrlich ascites carcinoma. It was shown that cancer grow is associated with the development of conditions in macrophages leading to a decrease in the substrate flow intensity in the tricarboxylic acid cycle, deceleration of oxidative deamination of L-glutamate, NADP regeneration, and a decrease in the antioxidant defense efficiency. There results are consistent with our recent concept on the nonspecific metabolic reaction of cells to extreme exposures.
作者简介
E. Inzhevatkin
Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the RAS
编辑信件的主要联系方式.
Email: inscience@mail.ru
俄罗斯联邦, Akademgorodok 50, Krasnoyarsk, 660036
A. Savchenko
Research Institute for Medical Problems in the North Division of Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the RAS”
Email: inscience@mail.ru
俄罗斯联邦, ul. Partizana Zheleznyaka 3 G, Krasnoyarsk, 660022
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