Physicochemical Properties and Anti-Opisthorchosis Effect of Mechanochemically Synthesized Solid Compositions of Praziquantel with Glycyrrhizic Acid Disodium Salt
- Autores: Meteleva E.S.1, Chistyachenko Y.S.1, Suntsova L.P.1, Tsyganov M.A.2, Vishnivetskaya G.B.2, Avgustinovich D.F.2, Khvostov M.V.3,4, Polyakov N.E.5, Tolstikova T.G.3,4, Mordvinov V.A.2, Dushkin A.V.1, Lyakhov N.Z.1
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Afiliações:
- Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch
- Institute of Cytology and Genetics, Siberian Branch
- Vorozhtsov Institute of Organic Chemistry, Siberian Branch
- Novosibirsk State University
- Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch
- Edição: Volume 481, Nº 1 (2018)
- Páginas: 228-231
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212415
- DOI: https://doi.org/10.1134/S1607672918040142
- ID: 212415
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Resumo
The mechanochemical preparation of solid compositions of praziquantel with plant saponin (glycyrrhizic acid disodium salt) is described. The study of a number of physicochemical parameters showed that dissolving solid compositions in water is accompanied by the inclusion of praziquantel molecules into micelles, which are formed in the solution of the glycyrrhizic acid disodium salt. Using the opisthorchiasis model caused by Opisthorchis felineus, we found a 4- to 11-fold increase in the anthelmintic activity of praziquantel in the composition as compared to the official praziquantel. According to the pharmacokinetic data, the use of the composition increased the bioavailability of praziquantel 3 times.
Sobre autores
E. Meteleva
Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch
Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630128
Yu. Chistyachenko
Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch
Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630128
L. Suntsova
Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch
Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630128
M. Tsyganov
Institute of Cytology and Genetics, Siberian Branch
Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630090
G. Vishnivetskaya
Institute of Cytology and Genetics, Siberian Branch
Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630090
D. Avgustinovich
Institute of Cytology and Genetics, Siberian Branch
Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630090
M. Khvostov
Vorozhtsov Institute of Organic Chemistry, Siberian Branch; Novosibirsk State University
Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630090; Novosibirsk, 630090
N. Polyakov
Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch
Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630090
T. Tolstikova
Vorozhtsov Institute of Organic Chemistry, Siberian Branch; Novosibirsk State University
Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630090; Novosibirsk, 630090
V. Mordvinov
Institute of Cytology and Genetics, Siberian Branch
Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630090
A. Dushkin
Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch
Autor responsável pela correspondência
Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630128
N. Lyakhov
Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch
Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630128
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