Physicochemical Properties and Anti-Opisthorchosis Effect of Mechanochemically Synthesized Solid Compositions of Praziquantel with Glycyrrhizic Acid Disodium Salt


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Resumo

The mechanochemical preparation of solid compositions of praziquantel with plant saponin (glycyrrhizic acid disodium salt) is described. The study of a number of physicochemical parameters showed that dissolving solid compositions in water is accompanied by the inclusion of praziquantel molecules into micelles, which are formed in the solution of the glycyrrhizic acid disodium salt. Using the opisthorchiasis model caused by Opisthorchis felineus, we found a 4- to 11-fold increase in the anthelmintic activity of praziquantel in the composition as compared to the official praziquantel. According to the pharmacokinetic data, the use of the composition increased the bioavailability of praziquantel 3 times.

Sobre autores

E. Meteleva

Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch

Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630128

Yu. Chistyachenko

Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch

Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630128

L. Suntsova

Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch

Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630128

M. Tsyganov

Institute of Cytology and Genetics, Siberian Branch

Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630090

G. Vishnivetskaya

Institute of Cytology and Genetics, Siberian Branch

Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630090

D. Avgustinovich

Institute of Cytology and Genetics, Siberian Branch

Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630090

M. Khvostov

Vorozhtsov Institute of Organic Chemistry, Siberian Branch; Novosibirsk State University

Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630090; Novosibirsk, 630090

N. Polyakov

Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch

Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630090

T. Tolstikova

Vorozhtsov Institute of Organic Chemistry, Siberian Branch; Novosibirsk State University

Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630090; Novosibirsk, 630090

V. Mordvinov

Institute of Cytology and Genetics, Siberian Branch

Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630090

A. Dushkin

Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch

Autor responsável pela correspondência
Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630128

N. Lyakhov

Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch

Email: dushkin@solid.nsc.ru
Rússia, Novosibirsk, 630128

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