The Status of the Hemostasis System under the Influence of Proline Peptides during the Development of Experimental Metabolic Syndrome
- Autores: Grigorjeva M.E.1, Myasoedov N.F.2, Lyapina L.A.1, Obergan T.Y.1, Andreeva L.A.2
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Afiliações:
- Faculty of Biology
- Institute of Molecular Genetics
- Edição: Volume 479, Nº 1 (2018)
- Páginas: 59-61
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212134
- DOI: https://doi.org/10.1134/S1607672918020011
- ID: 212134
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Resumo
A comparative study of the influence of regulatory proline peptides Pro–Gly–Pro, Pro–Arg–Pro, Pro–Gly–Pro–Leu, and Arg–Pro–Gly–Pro on the state of the hemostasis system was carried out in an experiment on male rats with metabolic syndrome. Under these conditions, repeated (7-fold) intranasal administration of the peptides in a daily dose of 50 μg/kg resulted in an increase in the anticoagulant potential of the blood, namely, in an increase in the anticoagulant, fibrinolytic, and antiplatelet activity 20 h and 7 days after the last peptide injection. The arginine–containing peptide Arg–Pro–Gly–Pro had the most pronounced and stable effect on haemostasis under these experimental conditions.
Sobre autores
M. Grigorjeva
Faculty of Biology
Autor responsável pela correspondência
Email: mgrigorjeva@mail.ru
Rússia, Moscow, 119992
N. Myasoedov
Institute of Molecular Genetics
Email: mgrigorjeva@mail.ru
Rússia, Moscow, 123182
L. Lyapina
Faculty of Biology
Email: mgrigorjeva@mail.ru
Rússia, Moscow, 119992
T. Obergan
Faculty of Biology
Email: mgrigorjeva@mail.ru
Rússia, Moscow, 119992
L. Andreeva
Institute of Molecular Genetics
Email: mgrigorjeva@mail.ru
Rússia, Moscow, 123182
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