The Status of the Hemostasis System under the Influence of Proline Peptides during the Development of Experimental Metabolic Syndrome


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A comparative study of the influence of regulatory proline peptides Pro–Gly–Pro, Pro–Arg–Pro, Pro–Gly–Pro–Leu, and Arg–Pro–Gly–Pro on the state of the hemostasis system was carried out in an experiment on male rats with metabolic syndrome. Under these conditions, repeated (7-fold) intranasal administration of the peptides in a daily dose of 50 μg/kg resulted in an increase in the anticoagulant potential of the blood, namely, in an increase in the anticoagulant, fibrinolytic, and antiplatelet activity 20 h and 7 days after the last peptide injection. The arginine–containing peptide Arg–Pro–Gly–Pro had the most pronounced and stable effect on haemostasis under these experimental conditions.

Sobre autores

M. Grigorjeva

Faculty of Biology

Autor responsável pela correspondência
Email: mgrigorjeva@mail.ru
Rússia, Moscow, 119992

N. Myasoedov

Institute of Molecular Genetics

Email: mgrigorjeva@mail.ru
Rússia, Moscow, 123182

L. Lyapina

Faculty of Biology

Email: mgrigorjeva@mail.ru
Rússia, Moscow, 119992

T. Obergan

Faculty of Biology

Email: mgrigorjeva@mail.ru
Rússia, Moscow, 119992

L. Andreeva

Institute of Molecular Genetics

Email: mgrigorjeva@mail.ru
Rússia, Moscow, 123182

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