Expression of transcription factor genes in cell lines corresponding to different stages of pancreatic cancer progression
- Авторы: Abjalimov I.R.1, Zinovyeva M.V.1, Nikolaev L.G.1, Kopantzeva M.R.1, Kopantzev E.P.1, Sverdlov E.D.1
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Учреждения:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Выпуск: Том 475, № 1 (2017)
- Страницы: 267-270
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211947
- DOI: https://doi.org/10.1134/S160767291704007X
- ID: 211947
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Аннотация
The expression level of six transcription factor genes and the content of their protein products in five pancreatic cancer cell lines with parallel control of expression of three marker genes reflecting epithelial or mesenchymal state of cells was investigated. Cell lines MIA PaCa-2 and Capan-2 represented the best models of quasi-mesenchymal and epithelial, respectively, types of progression of the pancreatic ductal adenocarcinoma, according to the content of E-cadherin and vimentin and the expression of KLF5 and ZEB1 transcription factors.
Об авторах
I. Abjalimov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: lev@ibch.ru
Россия, Moscow, 117997
M. Zinovyeva
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: lev@ibch.ru
Россия, Moscow, 117997
L. Nikolaev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Автор, ответственный за переписку.
Email: lev@ibch.ru
Россия, Moscow, 117997
M. Kopantzeva
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: lev@ibch.ru
Россия, Moscow, 117997
E. Kopantzev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: lev@ibch.ru
Россия, Moscow, 117997
E. Sverdlov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: lev@ibch.ru
Россия, Moscow, 117997
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