Отправить статью по E-mail The study of immunogenicity of the antigenic protein of high risk oncogenic type of the human papillomavirus HPV16 L1 produced in the plant expression system on the base of transgenic tomato
- Авторы: Salyaev R.K.1, Rekoslavskaya N.I.1,2, Stolbikov A.S.1, Tretyakova A.V.1
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Учреждения:
- Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch
- Irkutsk Research Center, Siberian Branch
- Выпуск: Том 474, № 1 (2017)
- Страницы: 186-188
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211896
- DOI: https://doi.org/10.1134/S1607672917030140
- ID: 211896
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Аннотация
The immunogenicity of plant-made peroral vaccine against cervical cancer was studied in mice during 342 days after vaccination with the material of tomato fruits genetically transformed with HPV16 L1 Ώ 5′UTR TMV. The immune response was found on day 4 after vaccination in blood serum of vaccinated mice. On days 90–100, the rise to maximum value of the level of antibodies to HPV16 L1 was in the range of 500 ng of the standard antibodies to HPV16 L1 (Santa Cruz Biotechnology, United States). This level of antibodies was retained until the end of the study.
Об авторах
R. Salyaev
Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch
Автор, ответственный за переписку.
Email: salyaev@sifibr.irk.ru
Россия, Irkutsk, 664033
N. Rekoslavskaya
Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch; Irkutsk Research Center, Siberian Branch
Email: salyaev@sifibr.irk.ru
Россия, Irkutsk, 664033; Irkutsk, 664033
A. Stolbikov
Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch
Email: salyaev@sifibr.irk.ru
Россия, Irkutsk, 664033
A. Tretyakova
Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch
Email: salyaev@sifibr.irk.ru
Россия, Irkutsk, 664033
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