Possible mechanism of bursting suppression in nociceptive neurons
- Авторы: Dick O.E.1, Krylov B.V.1, Nozdrachev A.D.1,2
-
Учреждения:
- Pavlov Institute of Physiology
- St. Petersburg State University
- Выпуск: Том 473, № 1 (2017)
- Страницы: 137-140
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211873
- DOI: https://doi.org/10.1134/S1607672917020120
- ID: 211873
Цитировать
Аннотация
The use of the mathematical model of rat nociceptive neuron membrane allowed us to predict a new mechanism of suppression of ectopic bursting discharges, which arise in neurons of dorsal root ganglia and are one of the causes of neuropathic pain. The treatment with comenic acid leads to switching off the ectopic bursting discharges due to a decrease in the effective charge transferring via the activation gating structure of the slow sodium channels (NaV1.8a). Comenic acid is a drug substance of a new non-opioid analgesic [1] Thus, this analgesic not only reduces the frequency of rhythmic discharges of nociceptive neuron membrane [2] but also it suppresses its ectopic bursting discharges.
Об авторах
O. Dick
Pavlov Institute of Physiology
Автор, ответственный за переписку.
Email: glazov.holo@mail.ioffe.ru
Россия, St. Petersburg, 199034
B. Krylov
Pavlov Institute of Physiology
Email: glazov.holo@mail.ioffe.ru
Россия, St. Petersburg, 199034
A. Nozdrachev
Pavlov Institute of Physiology; St. Petersburg State University
Email: glazov.holo@mail.ioffe.ru
Россия, St. Petersburg, 199034; Universitetskaya nab. 7/9, St. Petersburg, 199034
Дополнительные файлы
