Negative-sense virion RNA of segment 8 (NS) of influenza a virus is able to translate in vitro a new viral protein
- Autores: Zhirnov O.P.1, Akulich K.A.2, Lipatova A.V.1, Usachev E.V.1
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Afiliações:
- Ivanovsky Research Institute of Virology
- Belozerskii Institute of Physicochemical Biology
- Edição: Volume 473, Nº 1 (2017)
- Páginas: 122-127
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211865
- DOI: https://doi.org/10.1134/S1607672917020090
- ID: 211865
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Resumo
It was shown that full-length virion RNA of segment 8 of influenza virus A/Aichi/2/68 (H3N2) can initiate the synthesis of two major polypeptides with molecular weights of 23 and 13 kD and a minor polypeptide with a molecular weight of 19 kDa, which specifically reacted with the antibodies to the 30-membered peptide of the central part of the NSP protein of influenza A virus. Thus, the genomic-polarity RNA of segment 8 of influenza virus A has a translational template function. These data provide further confirmation of the concept of the bipolar (ambisens) strategy of functioning of the influenza A virus genome.
Sobre autores
O. Zhirnov
Ivanovsky Research Institute of Virology
Autor responsável pela correspondência
Email: zhirnov@inbox.ru
Rússia, Moscow, 123098
K. Akulich
Belozerskii Institute of Physicochemical Biology
Email: zhirnov@inbox.ru
Rússia, Moscow, 119992
A. Lipatova
Ivanovsky Research Institute of Virology
Email: zhirnov@inbox.ru
Rússia, Moscow, 123098
E. Usachev
Ivanovsky Research Institute of Virology
Email: zhirnov@inbox.ru
Rússia, Moscow, 123098
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