Signaling targets of alcoholic intoxication in human skeletal muscle
- Авторы: Mirzoev T.M.1, Lomonosova Y.N.1, Zinovyeva O.E.2, Lysenko E.A.1, Shenkman B.S.1, Nemirovskaya T.L.1,3
-
Учреждения:
- Institute of Biomedical Problems
- Sechenov First Moscow State Medical University, Ministry of Health Care of the Russian Federation
- Moscow State University
- Выпуск: Том 470, № 1 (2016)
- Страницы: 329-331
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211542
- DOI: https://doi.org/10.1134/S1607672916050069
- ID: 211542
Цитировать
Аннотация
Intracellular signaling pathways were investigated in skeletal muscle cells at the early stages of alcohol addiction manifestations. No muscle fiber atrophy was observed in m. vastus lateralis of male patients. No significant changes in the signaling mechanisms that control protein degradation were detected as well. However, the concentration of the insulin-like growth factor (IGF-1) in blood plasma as well as the content of markers of intracellular signaling pathways regulating protein synthesis were significantly reduced compared to the control group.
Об авторах
T. Mirzoev
Institute of Biomedical Problems
Email: nemirovskaya@bk.ru
Россия, Khoroshevskoe sh. 76-a, Moscow, 123007
Y. Lomonosova
Institute of Biomedical Problems
Email: nemirovskaya@bk.ru
Россия, Khoroshevskoe sh. 76-a, Moscow, 123007
O. Zinovyeva
Sechenov First Moscow State Medical University, Ministry of Health Care of the Russian Federation
Email: nemirovskaya@bk.ru
Россия, Moscow
E. Lysenko
Institute of Biomedical Problems
Email: nemirovskaya@bk.ru
Россия, Khoroshevskoe sh. 76-a, Moscow, 123007
B. Shenkman
Institute of Biomedical Problems
Email: nemirovskaya@bk.ru
Россия, Khoroshevskoe sh. 76-a, Moscow, 123007
T. Nemirovskaya
Institute of Biomedical Problems; Moscow State University
Автор, ответственный за переписку.
Email: nemirovskaya@bk.ru
Россия, Khoroshevskoe sh. 76-a, Moscow, 123007; Moscow, 119234
Дополнительные файлы
