Development of a biosensor for electrochemical detection of tumor-associated proteins in blood plasma of cancer patients by aptamers


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Аннотация

A molecular biosensor based on DNA aptamers (aptasensor) for the diagnosis of lung cancer in blood plasma samples was designed. To create the aptasensor, the aptamer 17_80, obtained in the study of postoperative material, was used. The affinity and binding selectivity of the aptamer 17_80 to the lung tumor tissue was confirmed on histological sections of postmortem samples of lung tissue. Using affinity enrichment and mass spectrometry, a possible target molecule of the aptamer 17_80, vimentin, was found.

Авторлар туралы

G. Zamay

Institute of Chemistry and Chemical Technology, Siberian Branch; Voino-Yasenetskii State Medical University

Email: tzamay@yhandex.ru
Ресей, Krasnoyarsk; ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, 660022

T. Zamay

Voino-Yasenetskii State Medical University

Хат алмасуға жауапты Автор.
Email: tzamay@yhandex.ru
Ресей, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, 660022

O. Kolovskaya

Institute of Chemistry and Chemical Technology, Siberian Branch; Voino-Yasenetskii State Medical University

Email: tzamay@yhandex.ru
Ресей, Krasnoyarsk; ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, 660022

A. Krat

Kryzhanovsky Krasnoyarsk Regional Cancer Clinic

Email: tzamay@yhandex.ru
Ресей, Krasnoyarsk, Krasnoyarsk Krai

Yu. Glazyrin

Institute of Chemistry and Chemical Technology, Siberian Branch; Voino-Yasenetskii State Medical University

Email: tzamay@yhandex.ru
Ресей, Krasnoyarsk; ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, 660022

A. Dubinina

Institute of Chemistry and Chemical Technology, Siberian Branch; Voino-Yasenetskii State Medical University

Email: tzamay@yhandex.ru
Ресей, Krasnoyarsk; ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, 660022

A. Zamay

Institute of Chemistry and Chemical Technology, Siberian Branch; Voino-Yasenetskii State Medical University

Email: tzamay@yhandex.ru
Ресей, Krasnoyarsk; ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk Krai, 660022

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