Enviar artigo por via de e-mail New Positive Allosteric Modulator of AMPA Receptors: in vitro and in vivo Studies
- Autores: Grigoriev V.V.1, Lavrov M.I.1,2, Zamoyski V.L.1, Garibova T.L.3, Palyulin V.A.1,2, Bachurin S.O.1
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Afiliações:
- Institute of Physiologically Active Compounds of the Russian Academy of Sciences
- Faculty of Chemistry, Moscow State University
- Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
- Edição: Volume 488, Nº 1 (2019)
- Páginas: 304-306
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213075
- DOI: https://doi.org/10.1134/S160767291905003X
- ID: 213075
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Resumo
A new derivative of 3,7-diazabicyclo[3.3.1]nonane, which showed a high activity as a positive allosteric modulator of AMPA receptors of the CNS, was studied in electrophysiological experiments. At doses of 0.01 mg/kg, this compound significantly improved the memory of experimental animals disturbed by maximal electric shock. The results indicate that this compound is a promising candidate for preclinical trials and clinical studies as a drug for treatment of a number of psychoneurological diseases.
Sobre autores
V. Grigoriev
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Email: vzam@yandex.ru
Rússia, Chernogolovka, Moscow Region, 142432
M. Lavrov
Institute of Physiologically Active Compounds of the Russian Academy of Sciences; Faculty of Chemistry, Moscow State University
Email: vzam@yandex.ru
Rússia, Chernogolovka, Moscow Region, 142432; Moscow, 119991
V. Zamoyski
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: vzam@yandex.ru
Rússia, Chernogolovka, Moscow Region, 142432
T. Garibova
Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: vzam@yandex.ru
Rússia, Moscow, 125315
V. Palyulin
Institute of Physiologically Active Compounds of the Russian Academy of Sciences; Faculty of Chemistry, Moscow State University
Email: vzam@yandex.ru
Rússia, Chernogolovka, Moscow Region, 142432; Moscow, 119991
S. Bachurin
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Email: vzam@yandex.ru
Rússia, Chernogolovka, Moscow Region, 142432
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