Amitriptyline Attenuates Ca 2+  Responses Induced by Glutoxim and Molixan in Macrophages

Z. I. Krutetskaya; L. S. Milenina; A. A. Naumova; S. N. Butov; V. G. Antonov; A. D. Nozdrachev

doi:10.1134/S1607672918040117

Amitriptyline Attenuates Ca²⁺ Responses Induced by Glutoxim and Molixan in Macrophages

Autores: Krutetskaya Z.I.¹, Milenina L.S.¹, Naumova A.A.¹, Butov S.N.¹, Antonov V.G.¹, Nozdrachev A.D.¹
Afiliações:
1. St. Petersburg State University
Edição: Volume 481, Nº 1 (2018)
Páginas: 222-224
Seção: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/212393
DOI: https://doi.org/10.1134/S1607672918040117
ID: 212393

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Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist, tricyclic antidepressant amitriptyline, significantly inhibits glutoxim- and molixan-induced Ca²⁺-responses in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca²⁺ concentration increase in macrophages.