Amitriptyline Attenuates Ca2+ Responses Induced by Glutoxim and Molixan in Macrophages


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Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist, tricyclic antidepressant amitriptyline, significantly inhibits glutoxim- and molixan-induced Ca2+-responses in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca2+ concentration increase in macrophages.

Sobre autores

Z. Krutetskaya

St. Petersburg State University

Autor responsável pela correspondência
Email: z.krutetskaya@spbu.ru
Rússia, St. Petersburg, 199034

L. Milenina

St. Petersburg State University

Email: z.krutetskaya@spbu.ru
Rússia, St. Petersburg, 199034

A. Naumova

St. Petersburg State University

Email: z.krutetskaya@spbu.ru
Rússia, St. Petersburg, 199034

S. Butov

St. Petersburg State University

Email: z.krutetskaya@spbu.ru
Rússia, St. Petersburg, 199034

V. Antonov

St. Petersburg State University

Email: z.krutetskaya@spbu.ru
Rússia, St. Petersburg, 199034

A. Nozdrachev

St. Petersburg State University

Email: z.krutetskaya@spbu.ru
Rússia, St. Petersburg, 199034

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