Amitriptyline Attenuates Ca2+ Responses Induced by Glutoxim and Molixan in Macrophages
- Autores: Krutetskaya Z.I.1, Milenina L.S.1, Naumova A.A.1, Butov S.N.1, Antonov V.G.1, Nozdrachev A.D.1
-
Afiliações:
- St. Petersburg State University
- Edição: Volume 481, Nº 1 (2018)
- Páginas: 222-224
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212393
- DOI: https://doi.org/10.1134/S1607672918040117
- ID: 212393
Citar
Resumo
Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist, tricyclic antidepressant amitriptyline, significantly inhibits glutoxim- and molixan-induced Ca2+-responses in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca2+ concentration increase in macrophages.
Sobre autores
Z. Krutetskaya
St. Petersburg State University
Autor responsável pela correspondência
Email: z.krutetskaya@spbu.ru
Rússia, St. Petersburg, 199034
L. Milenina
St. Petersburg State University
Email: z.krutetskaya@spbu.ru
Rússia, St. Petersburg, 199034
A. Naumova
St. Petersburg State University
Email: z.krutetskaya@spbu.ru
Rússia, St. Petersburg, 199034
S. Butov
St. Petersburg State University
Email: z.krutetskaya@spbu.ru
Rússia, St. Petersburg, 199034
V. Antonov
St. Petersburg State University
Email: z.krutetskaya@spbu.ru
Rússia, St. Petersburg, 199034
A. Nozdrachev
St. Petersburg State University
Email: z.krutetskaya@spbu.ru
Rússia, St. Petersburg, 199034
Arquivos suplementares
