A novel dimeric dipeptide mimetic of the BDNF selectively activates the MAPK-Erk signaling pathway
- Авторы: Gudasheva T.A.1, Tarasiuk A.V.1, Sazonova N.M.1, Povarnina P.Y.1, Antipova T.A.1, Seredenin S.B.1
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Учреждения:
- Zakusov Research Institute of Pharmacology
- Выпуск: Том 476, № 1 (2017)
- Страницы: 291-295
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211964
- DOI: https://doi.org/10.1134/S1607672917050027
- ID: 211964
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Аннотация
On the basis of the structure of beta-turn of loop 2 of brain-derived neurotrophic factor (BDNF), its new dimeric dipeptide mimetic bis-(N-hexanoyl-L-seryl-L-lysine) hexamethylenediamide (GTS-201) was created. It activated TrkB and Erk, did not activate Akt, and exhibited neuroprotective activity in vitro at concentrations of 10–5–10–8 M. Unlike the mimetics that activate Erk and Akt, GTS-201 did not exhibit antidepressant properties. For the manifestation of the antidepressant activity of BDNF mimetics, the activation of its both major signaling pathways is required.
Об авторах
T. Gudasheva
Zakusov Research Institute of Pharmacology
Автор, ответственный за переписку.
Email: tata-sosnovka@mail.ru
Россия, ul. Baltiiskaya 8, Moscow, 125315
A. Tarasiuk
Zakusov Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Россия, ul. Baltiiskaya 8, Moscow, 125315
N. Sazonova
Zakusov Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Россия, ul. Baltiiskaya 8, Moscow, 125315
P. Povarnina
Zakusov Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Россия, ul. Baltiiskaya 8, Moscow, 125315
T. Antipova
Zakusov Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Россия, ul. Baltiiskaya 8, Moscow, 125315
S. Seredenin
Zakusov Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Россия, ul. Baltiiskaya 8, Moscow, 125315
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