Immune response to Vi-antigen of  Salmonella typhi  is dependent on introduction of positive charge and shape of charged group into polysaccharide

A. V. Kolesnikov; A. V. Kozyr; A. K. Ryabko; I. G. Shemyakin; I. A. Dyatlov

doi:10.1134/S1607672917020132

Immune response to Vi-antigen of Salmonella typhi is dependent on introduction of positive charge and shape of charged group into polysaccharide

Authors: Kolesnikov A.V.¹, Kozyr A.V.¹, Ryabko A.K.¹, Shemyakin I.G.¹, Dyatlov I.A.¹
Affiliations:
1. State Research Center for Applied Microbiology and Biotechnology
Issue: Vol 473, No 1 (2017)
Pages: 141-144
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/211876
DOI: https://doi.org/10.1134/S1607672917020132
ID: 211876

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Abstract

A model of a controlled conversion of polysaccharide Vi-antigen of S. typhi into zwitterionic antigen is proposed. The immunological properties of modifications of this antigen conjugated to a protein support were studied.