Methyl-β-cyclodextrin modulates thapsigargin-induced store-dependent Ca2+ entry in macrophages
- Авторы: Krutetskaya Z.I.1, Milenina L.S.1, Naumova A.A.1, Butov S.N.1, Antonov V.G.1, Nozdrachev A.D.1
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Учреждения:
- St. Petersburg State University
- Выпуск: Том 473, № 1 (2017)
- Страницы: 88-90
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211849
- DOI: https://doi.org/10.1134/S1607672917020028
- ID: 211849
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Аннотация
Using Fura-2AM microfluorimetry, we have shown for the first time that preincubation of macrophages with methyl-β-cyclodextrin, inducing cholesterol extraction from membranes and raft disruption, leads to significant inhibition of thapsigargin-induced store-dependent Ca2+ entry in rat peritoneal macrophages. In contrast, macrophage treatment with methyl-β-cyclodextrin after Ca2+ entry mechanisms were activated by store depletion by thapsigargin application leads to potentiation of subsequent store-dependent Ca2+ entry. The results suggest that intact lipid rafts are necessary for the activation but not the maintenance of store-dependent Ca2+ entry in macrophages.
Об авторах
Z. Krutetskaya
St. Petersburg State University
Автор, ответственный за переписку.
Email: z.krutetskaya@spbu.ru
Россия, St. Petersburg, 199034
L. Milenina
St. Petersburg State University
Email: z.krutetskaya@spbu.ru
Россия, St. Petersburg, 199034
A. Naumova
St. Petersburg State University
Email: z.krutetskaya@spbu.ru
Россия, St. Petersburg, 199034
S. Butov
St. Petersburg State University
Email: z.krutetskaya@spbu.ru
Россия, St. Petersburg, 199034
V. Antonov
St. Petersburg State University
Email: z.krutetskaya@spbu.ru
Россия, St. Petersburg, 199034
A. Nozdrachev
St. Petersburg State University
Email: z.krutetskaya@spbu.ru
Россия, St. Petersburg, 199034
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