Drosophila polytene chromosome bands formed by gene introns


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Аннотация

Genetic organization of bands and interbands in polytene chromosomes has long remained a puzzle for geneticists. It has been recently demonstrated that interbands typically correspond to the 5’-ends of house-keeping genes, whereas adjacent loose bands tend to be composed of coding sequences of the genes. In the present work, we made one important step further and mapped two large introns of ubiquitously active genes on the polytene chromosome map. We show that alternative promoter regions of these genes map to interbands, whereas introns and coding sequences found between those promoters correspond to loose grey bands. Thus, a gene having its long intron “sandwiched” between to alternative promoters and a common coding sequence may occupy two interbands and one band in the context of polytene chromosomes. Loose, partially decompacted bands appear to host large introns.

Авторлар туралы

I. Zhimulev

Institute of Molecular and Cellular Biology, SB RAS; Novosibirsk State University

Email: zhimulev@mcb.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090

L. Boldyreva

Institute of Molecular and Cellular Biology, SB RAS

Email: zhimulev@mcb.nsc.ru
Ресей, Novosibirsk, 630090

O. Demakova

Institute of Molecular and Cellular Biology, SB RAS

Email: zhimulev@mcb.nsc.ru
Ресей, Novosibirsk, 630090

G. Poholkova

Institute of Molecular and Cellular Biology, SB RAS

Email: zhimulev@mcb.nsc.ru
Ресей, Novosibirsk, 630090

V. Khoroshko

Institute of Molecular and Cellular Biology, SB RAS

Email: zhimulev@mcb.nsc.ru
Ресей, Novosibirsk, 630090

T. Zykova

Institute of Molecular and Cellular Biology, SB RAS

Email: zhimulev@mcb.nsc.ru
Ресей, Novosibirsk, 630090

S. Lavrov

Institute of Molecular Genetics RAS

Хат алмасуға жауапты Автор.
Email: zhimulev@mcb.nsc.ru
Ресей, Moscow, 123182

E. Belyaeva

Institute of Molecular and Cellular Biology, SB RAS

Email: zhimulev@mcb.nsc.ru
Ресей, Novosibirsk, 630090

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