Drosophila polytene chromosome bands formed by gene introns
- Авторлар: Zhimulev I.F.1,2, Boldyreva L.V.1, Demakova O.V.1, Poholkova G.V.1, Khoroshko V.A.1, Zykova T.Y.1, Lavrov S.A.3, Belyaeva E.S.1
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Мекемелер:
- Institute of Molecular and Cellular Biology, SB RAS
- Novosibirsk State University
- Institute of Molecular Genetics RAS
- Шығарылым: Том 466, № 1 (2016)
- Беттер: 57-60
- Бөлім: Biochemistry, Biophysics and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/210987
- DOI: https://doi.org/10.1134/S1607672916010178
- ID: 210987
Дәйексөз келтіру
Аннотация
Genetic organization of bands and interbands in polytene chromosomes has long remained a puzzle for geneticists. It has been recently demonstrated that interbands typically correspond to the 5’-ends of house-keeping genes, whereas adjacent loose bands tend to be composed of coding sequences of the genes. In the present work, we made one important step further and mapped two large introns of ubiquitously active genes on the polytene chromosome map. We show that alternative promoter regions of these genes map to interbands, whereas introns and coding sequences found between those promoters correspond to loose grey bands. Thus, a gene having its long intron “sandwiched” between to alternative promoters and a common coding sequence may occupy two interbands and one band in the context of polytene chromosomes. Loose, partially decompacted bands appear to host large introns.
Негізгі сөздер
Авторлар туралы
I. Zhimulev
Institute of Molecular and Cellular Biology, SB RAS; Novosibirsk State University
Email: zhimulev@mcb.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090
L. Boldyreva
Institute of Molecular and Cellular Biology, SB RAS
Email: zhimulev@mcb.nsc.ru
Ресей, Novosibirsk, 630090
O. Demakova
Institute of Molecular and Cellular Biology, SB RAS
Email: zhimulev@mcb.nsc.ru
Ресей, Novosibirsk, 630090
G. Poholkova
Institute of Molecular and Cellular Biology, SB RAS
Email: zhimulev@mcb.nsc.ru
Ресей, Novosibirsk, 630090
V. Khoroshko
Institute of Molecular and Cellular Biology, SB RAS
Email: zhimulev@mcb.nsc.ru
Ресей, Novosibirsk, 630090
T. Zykova
Institute of Molecular and Cellular Biology, SB RAS
Email: zhimulev@mcb.nsc.ru
Ресей, Novosibirsk, 630090
S. Lavrov
Institute of Molecular Genetics RAS
Хат алмасуға жауапты Автор.
Email: zhimulev@mcb.nsc.ru
Ресей, Moscow, 123182
E. Belyaeva
Institute of Molecular and Cellular Biology, SB RAS
Email: zhimulev@mcb.nsc.ru
Ресей, Novosibirsk, 630090
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