Neuroprotective Action of Amidic Neurolipins in Models of Neurotoxicity on the Culture of Human Neural-Like Cells SH-SY5Y

M. G. Akimov; A. M. Ashba; E. V. Fomina-Ageeva; N. M. Gretskaya; N. F. Myasoedov; V. V. Bezuglov

doi:10.1134/S1607672919020182

Neuroprotective Action of Amidic Neurolipins in Models of Neurotoxicity on the Culture of Human Neural-Like Cells SH-SY5Y

Authors: Akimov M.G.¹, Ashba A.M.¹, Fomina-Ageeva E.V.¹, Gretskaya N.M.¹, Myasoedov N.F.², Bezuglov V.V.¹
Affiliations:
1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
2. Institute of Molecular Genetics, Russian Academy of Sciences
Issue: Vol 485, No 1 (2019)
Pages: 141-144
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/212951
DOI: https://doi.org/10.1134/S1607672919020182
ID: 212951

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Abstract

It was established that in neurodegeneration models in the human neuron-like cell line SH-SY5Y, amide derivatives of arachidonic and docosahexaenoic acids were inactive in experiments with MPP⁺ and CoCl₂ but protected from H₂O₂. The protective activity of neurolipins decreased in the series DHA-DA > AA-SER ≥ AA-GLY > AA-GABA ≥ AA-EA and was manifested starting from a concentration of 0.5 nM.