Neuroprotective Action of Amidic Neurolipins in Models of Neurotoxicity on the Culture of Human Neural-Like Cells SH-SY5Y

M. G. Akimov; A. M. Ashba; E. V. Fomina-Ageeva; N. M. Gretskaya; N. F. Myasoedov; V. V. Bezuglov

doi:10.1134/S1607672919020182

Neuroprotective Action of Amidic Neurolipins in Models of Neurotoxicity on the Culture of Human Neural-Like Cells SH-SY5Y

Авторлар: Akimov M.G.¹, Ashba A.M.¹, Fomina-Ageeva E.V.¹, Gretskaya N.M.¹, Myasoedov N.F.², Bezuglov V.V.¹
Мекемелер:
1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
2. Institute of Molecular Genetics, Russian Academy of Sciences
Шығарылым: Том 485, № 1 (2019)
Беттер: 141-144
Бөлім: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/212951
DOI: https://doi.org/10.1134/S1607672919020182
ID: 212951

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат
Рұқсат жабық

Рұқсат берілді
Рұқсат жабық

Тек жазылушылар үшін

Аннотация
Авторлар туралы
Әдебиет тізімі
Қосымша файлдар
Статистика

Аннотация

It was established that in neurodegeneration models in the human neuron-like cell line SH-SY5Y, amide derivatives of arachidonic and docosahexaenoic acids were inactive in experiments with MPP⁺ and CoCl₂ but protected from H₂O₂. The protective activity of neurolipins decreased in the series DHA-DA > AA-SER ≥ AA-GLY > AA-GABA ≥ AA-EA and was manifested starting from a concentration of 0.5 nM.