The Development and Inmmunochemical Properties of the Dimer of Immunoglobulin A Specific to the Influenza Virus A Hemagglutinin

T. K. Aliev; I. G. Dement’eva; V. A. Toporova; V. V. Argentova; L. P. Pozdnyakova; M. N. Bokov; D. A. Dolgikh; P. G. Sveshnikov; M. P. Kirpichnikov

doi:10.1134/S160767291801009X

The Development and Inmmunochemical Properties of the Dimer of Immunoglobulin A Specific to the Influenza Virus A Hemagglutinin

Авторлар: Aliev T.K.¹, Dement’eva I.G.², Toporova V.A.², Argentova V.V.¹, Pozdnyakova L.P.², Bokov M.N.², Dolgikh D.A.¹^,3, Sveshnikov P.G.², Kirpichnikov M.P.¹^,3
Мекемелер:
1. Faculty of Biology
2. All-Russia Research Center of Molecular Diagnostics and Therapy
3. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Шығарылым: Том 478, № 1 (2018)
Беттер: 34-36
Бөлім: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/212094
DOI: https://doi.org/10.1134/S160767291801009X
ID: 212094

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We obtained dimeric forms of IgA1- and IgA2m1-isotypes of FI6 antibody broadly specific to hemagglutinins of different subtypes of influenza A virus. It was shown that the dimers of IgA1 isotype are characterized by a higher antigen-binding activity compared to the IgA2m1 dimers. The affinity of IgA1 dimers to the strains of the H1N1 subtype is higher than that of the H3N2 subtype, which correlates with the properties of the parental human FI6 antibody.