Involvement of transcription factor Oct-1 in the regulation of JAK–STAT signaling pathway in cells of Burkitt lymphoma

E. V. Pankratova; A. G. Stepchenko; I. D. Krylova; T. N. Portseva; S. G. Georgieva

doi:10.1134/S1607672916030200

Involvement of transcription factor Oct-1 in the regulation of JAK–STAT signaling pathway in cells of Burkitt lymphoma

Авторлар: Pankratova E.V.¹, Stepchenko A.G.¹, Krylova I.D.², Portseva T.N.¹, Georgieva S.G.¹
Мекемелер:
1. Engelhardt Institute of Molecular Biology
2. Moscow State Pedagogical University
Шығарылым: Том 468, № 1 (2016)
Беттер: 229-231
Бөлім: Biochemistry, Biophysics and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/211337
DOI: https://doi.org/10.1134/S1607672916030200
ID: 211337

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Аннотация

We studied the role of transcription factor Oct-1 in the regulation of expression of genes of the JAK–STAT signaling pathway in the Namalwa Burkitt’s lymphoma cell line. Overexpression of Oct-1 isoforms (Oct-1A, Oct-1L, and Oct-1X) causes a decrease in the activity of four genes involved in the JAK–STAT signaling pathway—IFNAR2, STAT1, STAT2, and STAT4. As a result of our research, it was found that genes STAT2 and STAT4 are direct targets for Oct-1 protein.