PRE/TRE elements act as transcription activators in  Drosophila  S2 Cells

D. A. Chetverina; A. V. Mikhailova; P. G. Georgiev; M. M. Erokhin

doi:10.1134/S1607672917010161

PRE/TRE elements act as transcription activators in Drosophila S2 Cells

Authors: Chetverina D.A.¹, Mikhailova A.V.¹, Georgiev P.G.¹, Erokhin M.M.¹
Affiliations:
1. Institute of Gene Biology
Issue: Vol 472, No 1 (2017)
Pages: 68-70
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/211828
DOI: https://doi.org/10.1134/S1607672917010161
ID: 211828

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Abstract

The Drosophila PRE/TRE elements are DNA targets for Polycomb and Trithorax group proteins, which control repression and activation of gene transcription, respectively. In this study, we show that, in transiently transfected Drosophila S2 cells, bxdPRE activates transcription driven from different promoters. Using CG32795 gene promoter, we demonstrate that other PRE/TRE elements—Fab7, en, eve, and CycB—also act as transcription activators in this model system.