Enviar artigo por via de e-mail Antitumor efficacy of combined gene and radiotherapy in animals
- Autores: Bezborodova O.A.1, Nemtsova E.R.1, Gevorkov A.R.1, Boyko A.V.1, Venediktova J.B.1, Alekseenko I.V.2,3, Kostina M.B.3, Monastyrskaya G.S.3, Sverdlov E.D.2,3, Khmelevskiy E.V.1, Yakubovskaya R.I.1
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Afiliações:
- National Medical Research Radiological Center (NMRRC)
- Institute of Molecular Genetics
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Edição: Volume 470, Nº 1 (2016)
- Páginas: 345-348
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211580
- DOI: https://doi.org/10.1134/S1607672916050112
- ID: 211580
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Resumo
Antitumor efficacy of the combined suicide gene therapy and radiotherapy was studied on the model of CT26 murine colon adenocarcinoma. CMV-FCU1-IRES-mGM-CSF-pGL3 construct with PEG-PEI-TAT (FCU1–mGM/5-FC) block copolymer as a vector was used for intratumoral administration. Tumors were irradiated with a single 5 Gy dose. The efficacy was evaluated according to the grade of tumor growth inhibition (T/C) and lifespan of the animals. Pronounced antitumor activity of the combined use of FCU1–mGM/5-FC system with radiotherapy on the background of prolonged lifespan and the synergism of the applied methods was revealed.
Sobre autores
O. Bezborodova
National Medical Research Radiological Center (NMRRC)
Autor responsável pela correspondência
Email: olgabezborodova@yandex.ru
Rússia, Obninsk, Kaluga oblast
E. Nemtsova
National Medical Research Radiological Center (NMRRC)
Email: olgabezborodova@yandex.ru
Rússia, Obninsk, Kaluga oblast
A. Gevorkov
National Medical Research Radiological Center (NMRRC)
Email: olgabezborodova@yandex.ru
Rússia, Obninsk, Kaluga oblast
A. Boyko
National Medical Research Radiological Center (NMRRC)
Email: olgabezborodova@yandex.ru
Rússia, Obninsk, Kaluga oblast
J. Venediktova
National Medical Research Radiological Center (NMRRC)
Email: olgabezborodova@yandex.ru
Rússia, Obninsk, Kaluga oblast
I. Alekseenko
Institute of Molecular Genetics; Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: olgabezborodova@yandex.ru
Rússia, pl. Akademika Kurchatova 46, Moscow, 123182; ul. Miklukho-Maklaya 16/10, Moscow, 117997
M. Kostina
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: olgabezborodova@yandex.ru
Rússia, ul. Miklukho-Maklaya 16/10, Moscow, 117997
G. Monastyrskaya
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: olgabezborodova@yandex.ru
Rússia, ul. Miklukho-Maklaya 16/10, Moscow, 117997
E. Sverdlov
Institute of Molecular Genetics; Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: olgabezborodova@yandex.ru
Rússia, pl. Akademika Kurchatova 46, Moscow, 123182; ul. Miklukho-Maklaya 16/10, Moscow, 117997
E. Khmelevskiy
National Medical Research Radiological Center (NMRRC)
Email: olgabezborodova@yandex.ru
Rússia, Obninsk, Kaluga oblast
R. Yakubovskaya
National Medical Research Radiological Center (NMRRC)
Email: olgabezborodova@yandex.ru
Rússia, Obninsk, Kaluga oblast
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