Methylglyoxal as a scavenger for superoxide anion-radical
- Autores: Shumaev K.B.1, Lankin V.Z.2, Konovalova G.G.2, Grechnikova M.A.2, Tikhaze A.K.2
-
Afiliações:
- Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology,”
- Russian Cardiology Research and Production Association
- Edição: Volume 469, Nº 1 (2016)
- Páginas: 305-308
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211498
- DOI: https://doi.org/10.1134/S1607672916040189
- ID: 211498
Citar
Resumo
Methylglyoxal at a concentration of 5 mM caused a significant inhibition of superoxide anion radical (O2·-) comparable to the effect of Tirone. In the process of O2·- generation in the system of egg phosphatidylcholine liposome peroxidation induced by the azo-initiator AIBN, a marked inhibition of chemiluminescence in the presence of 100 mM methylglyoxal was found. At the same time, methylglyoxal did not inhibit free radical peroxidation of low-density lipoprotein particles, which indicates the absence of interaction with methylglyoxal alkoxyl and peroxyl polyenoic lipid radicals. These findings deepen information about the role of methylglyoxal in the regulation of free radical processes.
Sobre autores
K. Shumaev
Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology,”
Autor responsável pela correspondência
Email: gavakon5050@mail.ru
Rússia, Leninskii pr. 33, Moscow, 119071
V. Lankin
Russian Cardiology Research and Production Association
Email: gavakon5050@mail.ru
Rússia, 3-ya Cherepkovskaya ul. 15a, Moscow, 121552
G. Konovalova
Russian Cardiology Research and Production Association
Email: gavakon5050@mail.ru
Rússia, 3-ya Cherepkovskaya ul. 15a, Moscow, 121552
M. Grechnikova
Russian Cardiology Research and Production Association
Email: gavakon5050@mail.ru
Rússia, 3-ya Cherepkovskaya ul. 15a, Moscow, 121552
A. Tikhaze
Russian Cardiology Research and Production Association
Email: gavakon5050@mail.ru
Rússia, 3-ya Cherepkovskaya ul. 15a, Moscow, 121552
Arquivos suplementares
