Choleretic effect of the complex plant supplement in experimental liver damage

Relevance. The search for supplements with choleretic activity is of great interest due to their detoxicant properties and possible hepatoprotective effect.

The aim of our study was to evaluate choleretic effect of the complex plant supplement comprised of Hypecoum erectum L.; Hedysarum dahuricum Turcz. ex B.Fedtsch.; Glycyrrhiza uralensis Fisch. ex DC.; Calendula officinalis L.; Scutellaria baicalensis Georgi. dry extracts.

Material and methods. The research was conducted on an animal model of acute liver damage induced by CCl₄ in 84 albino Wistar rats. The studied complex plant supplement was researched in doses of 100mg/kg, 200 mg/kg and 300 mg/kg in the course of 14 days starting from the 2^nd day of the experiment. Choleretic properties were evaluated by both the speed of bile secretion (mg/min) per 100 g of animal weight and the total amount of bile secreted during four hours of observation.

Results. It has been established that the use of the dry extract in tetrachloromethane hepatitis in white rats has a choleretic effect characterized by an increase in the rate of bile secretion, an increase in the amount of discharged bile and the growing concentration of bile acids.