X-ray fluorescence determination of silver in colloidal solutions
- Autores: Kolyabina E.S.1, Maksimova T.V.1, Pleteneva T.V.1, Syroeshkin A.V.1
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Afiliações:
- RUDN University
- Edição: Volume 26, Nº 4 (2023)
- Páginas: 28-31
- Seção: Pharmaceutical chemistry
- URL: https://journals.rcsi.science/1560-9596/article/view/143128
- DOI: https://doi.org/10.29296/25877313-2023-04-05
- ID: 143128
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Resumo
Objective. To develop the basics of technology for X-ray fluorescence determination of silver in colloidal solutions.
Relevance. Silver preparations are interesting as an alternative to antibiotics. Сurrently on the pharmaceutical market there is a large number of silver-containing colloidal dietary supplements, 70% of which contain silver in ionic form. The energy dispersive method of X-ray fluorescence analysis is an express method without long-term sample preparation.
Materials and methods. Silver proteinate (~8% Ag), Sigma-Aldrich; ProtargolLor (P.J.S.C. “Pharmstandard”, Kursk); Sialor (J.S.C. RENEWAL®); Argitos colloidal silver (“Nanosphere”, Russia), Argent Colloidal (Nutri expert, France). Dual Laser Light Scattering 2D-DLS (Zetasizer Malvern). Energy dispersive spectrometer Shimadzu EDX-7000 (Japan); OriginLab Corporation, USA.
Results. The technology of the X-ray fluorescence determination of silver in colloidal solutions from various companies was described in this paper. The present study has exploited the energy dispersive spectrometer Shimadzu EDX-7000 (Japan). The fluorescence intensity at AgKα = 22.105 keV depends linearly on the silver concentration in the range of 0.01% - 1% according to the equation I = (5.1 ± 0.1) · СAg for silver nitrate and I = (1.64 ± 0.03) · CAg for silver proteinate, which is due to the effect of the organic matrix.
Conclusion. The new XRF method was applied for quality control of protargol and other Ag-containing drugs and parapharmaceuticals.
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##article.viewOnOriginalSite##Sobre autores
E. Kolyabina
RUDN University
Autor responsável pela correspondência
Email: ks.kolyabina@gmail.com
Post-graduate Student, Department of Pharmaceutical and Toxicological Chemistry
Rússia, MoscowT. Maksimova
RUDN University
Email: ks.kolyabina@gmail.com
Ph.D. (Pharm.), Associate Professor, Department of Pharmaceutical and Toxicological Chemistry
Rússia, MoscowT. Pleteneva
RUDN University
Email: ks.kolyabina@gmail.com
Dr.Sc. (Chem.), Professor, Department of Pharmaceutical and Toxicological Chemistry
Rússia, MoscowA. Syroeshkin
RUDN University
Email: ks.kolyabina@gmail.com
Dr.Sc. (Biol.), Professor, Head of Department of Pharmaceutical and toxicological Chemistry
Rússia, MoscowBibliografia
- Gosudarstvennaja farmakopeja Rossijskoj Federacii XIV izdanija. FS Serebra proteinat vzamen FS 42-1573-88/2018.
- Kumar A., Goia D.V. Comparative Analysis of Commercial Colloidal Silver Products. Int. J. Nanomedicine. 2020; 15: 10425–10434.
- Talarska P., Boruczkowski M., Z ̇urawski J. Current Knowledge of Silver and Gold Nanoparticles in Laboratory Research – Application, Toxicity, Cellular Uptake. Nanomaterials. 2021; 11: 2454.
- Makarova M.P., Syroeshkin A.V., Maksimova T.V., Matveeva I.S., Pletenjova T.V. Osobennosti jekspress-opre-delenija mikrojelementov v lekarstvennyh i neoficinal'nyh rastenijah. Razrabotka i registracija lekarstvennyh sredstv. 2019; 8(2): 93–97.
- Hadrup N., Lam H.R. Oral toxicity of silver ions, silver nanoparticles and colloidal silver -a review. Regul. Toxicol. Pharmacol. 2014; 68(1): 1–7.
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