The development of the composition and technological process for capsules containing (Cichorium intybus L.) herb dried extract
- Authors: Kachalina T.V.1, Malysheva N.А.1, Semkina О.А.1, Beloshapkina О.М.1
-
Affiliations:
- All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
- Issue: Vol 28, No 9 (2025)
- Pages: 12-20
- Section: Pharmaceutical chemistry
- URL: https://journals.rcsi.science/1560-9596/article/view/310633
- DOI: https://doi.org/10.29296/25877313-2025-09-02
- ID: 310633
Cite item
Open Access
Access granted
Subscription Access
Abstract
Introduction. Currently, the range of domestic medicines for the treatment of gastrointestinal, liver and kidney diseases is insufficient to meet the needs of the Russian population. Biologically active food supplements, which are widely used by Russians as a substitute for herbal medicines, do not address the issue of preventing and treating this group of conditions.
The aim of this study is to develop a composition and process for producing an oral dosage form – capsules containing a dry extract from the herb Cichorium intybus.
Material and method. The object of the research is the dry extract of chicory (Cichorium intybus L.), obtained from wild plant material. The excipients used in the formulation comply with relevant regulatory standards and are approved for use in medicinal preparations. This research was conducted using the methods outlined in the official standards of the 15th edition of the State Pharmacopoeia of the Russian Federation.
Results. Based on the study of the physical, chemical, and technological properties of the substance, various compositions of the extract with auxiliary substances were selected. The quality indicators of the extract and capsule mass were determined. Experimental samples were produced by sequentially mixing medicinal and auxiliary substances; pharmaceutical and technological tests were conducted. It was found that the optimal composition has microcrystalline cellulose, lactose monohydrate, and calcium stearate as auxiliary substances.
Conclusions. The composition and process for producing capsules containing a dry extract from the herb, chicory, have been developed. Stability of the capsules during storage over a period of two years and three months was investigated, and the shelf life was determined to be two years.
Full Text
##article.viewOnOriginalSite##About the authors
T. V. Kachalina
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Author for correspondence.
Email: kachalina_tat@bk.ru
ORCID iD: 0000-0002-3459-5335
SPIN-code: 4334-9912
Ph.D. (Pharm.), Leading Research Scientist, Experimental and Technological Department
Russian Federation, 7 Green str., Moscow, 117216N. А. Malysheva
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Email: proeko@yandex.ru
ORCID iD: 0000-0003-3336-4428
SPIN-code: 4278-5219
Senior Research Scientist, Experimental and Technological Department
Russian Federation, 7 Green str., Moscow, 117216О. А. Semkina
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Email: semkina@vilarnii.ru
ORCID iD: 0000-0002-2611-4490
SPIN-code: 1637-9398
Ph.D. (Pharm.), Leading Research Scientist, Experimental and Technological Department
Russian Federation, 7 Green str., Moscow, 117216О. М. Beloshapkina
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
Email: olga.beloshap@mail.ru
ORCID iD: 0000-0003-1743-1176
SPIN-code: 6071-0474
Junior Research Scientist, Experimental and Technological Department
Russian Federation, 7 Green str., Moscow, 117216References
- Saybel O.L., Radimich A.I., Dargaeva T.D. et al. Phenolic Compounds and Hepatoprotective Activity of Chicory Herb Extract. Drug development & registration. 2021; 10(4): 36–45. (In Russ.). doi: 10.33380/2305-2066-2021-10-4-36-45.
- Saybel O.L., Rendyuk T.D., Dargaeva T.D. et al. Phenolic compounds and immunomodulating activity of chicory (Cichorium intybus L.) extract. Pharmacognosy Journal. 2020; 12(5): 1104–1107. doi: 10.5530/pj.2020.12.156.
- Kachalina T.V., Malysheva N.A., Semkina O.A. Technological approaches to the creation of solid dosage forms with substances of plant origin. Journal of Pharmaceuticals Quality Assurance Issues. 2022; 2(36): 18–27. (In Russ.). doi: 10.34907/JPQAI.2022.38.15.003.
- Kachalina T.V., Malysheva N.A. Razrabotka tverdoj lekarstvennoj formy jekstrakta travy cikorija obyknovennogo. Innоvatiоns in life sсienсes: sbornik materialov IV mezhdunarodnogo simpoziuma. 2022; 237–239. (In Russ.).
- Saybel O.L. Justification and choice of method herb cichory standardization (Cichorium intybus L.). 2021; 2(32): 4–11. (In Russ.). DOI: 10.34907/ jpqai.2021.52.51.002.
- Lupanova I.A., Ferubko E.V., Kurmanova E.N. et al. Experimental study of the anti-inflammatory activity of the herb dry extract Cichorium intybus L. in vivo. Sbornik materialov jubilejnoj mezhdunarodnoj nauchnoj konferencii «90 let – ot rastenija do lekarstvennogo preparata: dostizhenija i perspektivy». 2021: 563–567. (In Russ.). doi: 10.52101/9785870191003_2021_563.
- Saybel O.L., Radimich A.I., Dargaeva T.D. et al. Method for producing a medicinal product exhibiting hepatoprotective and antihepatotoxic actions. RU 2771028 C1. 25.04.2022. (In Russ.).
Supplementary files
