Changes in the serum levels of anti-inflammatory interleukins in patients with atopic dermatitis after a course of phototherapy
- 作者: Plakhova K.1, Khasanova A.1, Tarasenko G.1, Shadyzheva L.1
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隶属关系:
- Russian Medical Academy of Continuous Postgraduate Education
- 期: 卷 23, 编号 5 (2020)
- 页面: 317-323
- 栏目: CLINICAL PICTURE, DIAGNOSIS, AND THERAPY OF DERMATOSES
- URL: https://journals.rcsi.science/1560-9588/article/view/49848
- DOI: https://doi.org/10.17816/dv49848
- ID: 49848
如何引用文章
详细
BACKGROUND: The role of immunological disorders in the development of atopic dermatitis (AD) is currently beyond doubt.
AIMS: Changes in the serum levels of IL-4, IL-10 and IL-13 in patients with atopic dermatitis (AD) after UV therapy combined with standard drug treatment have been studied.
MATERIALS AND METHODS: The study included 80 patients with moderate to severe AD and 80 healthy volunteers. The patients with AD received a course of 311 nm UVB phototherapy combined with standard drug therapy. Serum IL-4, IL-10 and IL-13 levels were determined through enzyme-linked immunosorbent assay (ELISA).
RESULTS: In the studied sample, patients with AD were found to have statistically significantly higher serum levels of IL-10 and IL-13 compared with healthy volunteers of the control group. Serum IL-10 level was 18.3 pg/ml in patients with AD and 13.2 pg/ml in those of the control group; the level of IL-13 was 15.8 pg/ml and 11.5 pg/ml, respectively; after the course of 311 nm UVB, serum IL-10 and IL-13 levels in patients with AD decreased (IL-10 by 27.8% and IL-13 by 12.5%). IL-4 values did not differ significantly in patients with AD and those in the control group, being 0.06 pg/ml and 0.05 pg/ml, respectively; after the course of phototherapy, serum IL-4 levels remained unchanged and were equal to 0.05 pg/ml.
CONCLUSION: The results obtained confirm the assumptions about the significant role of IL-10 and IL-13 in the mechanisms of AD regulation and pathogenesis and demonstrate the anti-inflammatory efficacy of phototherapy (311 nm UVB) in patients with severe and moderate AD.
作者简介
Kseniya Plakhova
Russian Medical Academy of Continuous Postgraduate Education
编辑信件的主要联系方式.
Email: plahova_xenia@mail.ru
ORCID iD: 0000-0003-4169-4128
MD, PhD, DSc, docent of Dermatovenerology and Cosmetology Department
俄罗斯联邦, MoscowA. Khasanova
Russian Medical Academy of Continuous Postgraduate Education
Email: plahova_xenia@mail.ru
ORCID iD: 0000-0001-7884-6442
俄罗斯联邦, Moscow
G. Tarasenko
Russian Medical Academy of Continuous Postgraduate Education
Email: plahova_xenia@mail.ru
ORCID iD: 0000-0001-6504-4782
俄罗斯联邦, Moscow
L. Shadyzheva
Russian Medical Academy of Continuous Postgraduate Education
Email: plahova_xenia@mail.ru
SPIN 代码: 4199-0359
俄罗斯联邦, Moscow
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