Acne, the microbiome and innate immunity


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In the laste years several articles focalized on human microbioma - the microorganisms from skin, mucosae, bowel - and on its role in chronic inflammatory diseases of the skin as acne, rosacea, atopic dermatitis, seborrheic dermatitis. In this article the authors present an update on particular acne skin’s microbioma, on innate immunity in acne and new physiopathology mecanisms described in inflammatory process in acne, and at the end we present in vitro, ex vivo and in vivo studies on the microbioma modulation and microbiofilm of pathogenic ribotypes of P. acnes leading to a significant improvement of acne in a series of 74 acne patients.

作者简介

Marius-Anton Ionescu

University Paris VII

Email: dr.toni.ionescu@gmail.com.
MD, PhD Dermatology Outpatient Clinic University Hospital «Saint-Louis»-Paris VII 1, Avenue Claude Vellefaux 75745 Paris cedex 10 France

Marc Feuiolley

Universite de Rouen

Laboratoire de microbiologie, signaux et microenvironnement EA 4312

Jeremy Enault

Universite de Rouen

Laboratoire de microbiologie, signaux et microenvironnement EA 4312

Pierre Wolkenstein

University Paris XII

Dermatology Department, University Hopsital «Henry Mondor» Creteil

Geraldine Robert

R&D - Laboratoires Dermatologiques d’Uriage

Neuilly-sur-Seine, France

Luc Lefeuvre

R&D - Laboratoires Dermatologiques d’Uriage

Neuilly-sur-Seine, France

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