IgM Antibodies to Mycobacterium leprae Dis-BSA semisynthetic antigen in residents of an endemic and nonendemic regions of Russia


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Blood levels of IgM antibodies to Mycobacterium leprae antigen were studied in healthy donors by enzyme immunoassay. Semisynthetic analog of M. leprae species-specific phenol glycoprotein (disaccharide conjugate with bovine serum albumin - Dis-BSA) from WHO bank served as the immunoadsorbent (antigen). The incidence of serum IgM antibodies to M. leprae Dis-BSA was higher in residents of the lepra endemic Astrakhan region (3,47% of 837 tested donors) in comparison with residents of Moscow and the Moscow Region, not lepra-endemic (2,05% of 781 tested donors). These data reflected the contacts of the population with the disease agent.

作者简介

O. Degtyarev

Astrakhan State Medical University; Institute of Lepra Research

доктор мед. наук, профессор 414000, Astrakhan, Russia

Sergey Rotanov

State Center of Dermatovenereology and Cosmetology

Email: rotanov@cnikvi.ru
MD, PhD, docent 107076, Moscow, Russia

Z. Ibadulaev

Institute of Lepra Research

Email: zagid30@rambler.ru
младший научный сотрудник 414057, Astrakhan

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