Chronic urticaria associated with primary biliary cirrhosis


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Chronic urticaria (CU) is one of the 20 most prevalent cutaneous diseases. It is associated with spontaneous weals, itching, and/or angioedemas persisting 6 weeks or longer. The cause of CU remains obscure in 7090% cases, in the rest cases the disease can be due to concomitant diseases, including autoimmune ones. We offer one of the first descriptions of CU associated with a rare autoimmune disease - primary biliary cirrhosis (PBC) in a female patient aged 30 years. In recent time three cases with CU associated with PBC (including cases with normal level of hepatic enzymes) have been descibed, which may indicate a relationship between these two diseases. In our observation PBC was asymptomatic for a long time, but with concomitant urticaria and high levels of hepatic enzymes and specific autoantibodies. Our data indicate the need in more profound immunological diagnosis in some cases, even with slight CU, good quality of life, response to treatment, and without other symptoms of PBC..

作者简介

P. Kolkhir

I.M.Setchenov First Moscow Medical University

Email: arthate@yandex.ru
кандидат мед. наук, старший научный сотрудник; Научно-исследовательский отдел иммунозависимых дерматозов Научно-исследовательского центра

I. Dzhavakhishvili

I.M.Setchenov First Moscow Medical University

ординатор; Кафедра кожных и венерических болезней лечебного факультета

N. Kochergin

I.M.Setchenov First Moscow Medical University

доктор мед. наук, профессор; Научно-исследовательский отдел иммунозависимых дерматозов Научно-исследовательского центра; Кафедра кожных и венерических болезней лечебного факультета

T. Nekrasova

I.M.Setchenov First Moscow Medical University

кандидат мед.наук, доцент; Кафедра патологической анатомии им. акад. А.И. Струкова

T. Rozina

I.M.Setchenov First Moscow Medical University; M.V. Lomonosov Moscow State University

кандидат мед. наук, доцент; Научно-исследовательский отдел здоровьесберегающих технологий Научно-исследовательского центра; Кафедра внутренних болезней факультета фундаментальной медицины Ф

参考

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