Metabolic screening as a tool for assessing the pathogenesis and course of psoriasis

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Psoriasis is a chronic, autoinflammatory/autoimmune systemic skin disease. The etiology and pathogenesis of the disease are still unclear. However, Th17/IL-17 activation and abnormalities in the Th17/Treg balance axis are observed in psoriasis, but this pathomechanism does not fully explain the frequent occurrence of metabolic disorders. Therefore, it is necessary to search for better biomarkers in the diagnosis, prognosis and monitoring of comorbid disorders and therapeutic effects in psoriasis.

Metabolomics is a new technology that allows to identify a set of small molecular chemicals involved in metabolism. This method has traditionally been studied with the aim of identifying biomarkers in the diagnosis and prognosis of the disease. Metabolic screening is essential for clinical diagnosis, therapeutic monitoring, predicting the efficacy of psoriasis treatment, and further discovery of new metabolic-based therapeutic targets.

Pharmacometabolomics is aimed at predicting individual differences in response to treatment and in the development of side effects associated with specific drugs.

This review summarizes studies that show responses to drug treatment based on their metabolic profiles obtained before, during, or after therapeutic intervention.

作者简介

Olga Olisova

I.M. Sechenov First Moscow State Medical University

编辑信件的主要联系方式.
Email: olisovaolga@mail.ru
ORCID iD: 0000-0003-2482-1754
SPIN 代码: 2500-7989

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, Moscow

Vladimir Kukes

I.M. Sechenov First Moscow State Medical University

Email: elmed@yandex.ru
ORCID iD: 0000-0002-5112-6928
SPIN 代码: 8498-3521

MD, Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences

俄罗斯联邦, Moscow

Ilya Kukes

I.M. Sechenov First Moscow State Medical University

Email: ilyakukes@gmail.com
ORCID iD: 0000-0003-1449-8711
SPIN 代码: 1166-3569

MD, Cand. Sci. (Med.), Research Associate

俄罗斯联邦, Moscow

Dmitry Ignatiev

I.M. Sechenov First Moscow State Medical University

Email: dmitrywork@list.ru
ORCID iD: 0000-0001-8751-3965
SPIN 代码: 6743-7960

MD

俄罗斯联邦, Moscow

Veronika Rogacheva

I.M. Sechenov First Moscow State Medical University

Email: rogacheva-90@mail.ru
ORCID iD: 0000-0003-4200-7887
SPIN 代码: 6164-1817

Graduate Student

俄罗斯联邦, Moscow

参考

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版权所有 © Olga Yu. Olisova, Vladimir G. Kukes, Ilya V. Kukes, Dmitry V. Ignatiev, Veronika V. Rogacheva, 2022

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