Chronicles of A.I. Pospelov Moscow Dermatovenerology and Cosmetology Society (MSDC was founded on October 4, 1891) Bulletin of the MSDC № 1146

On February 15, 2022, the 1146th meeting of the Moscow Society of Dermatovenereologists and Cosmetologists named after A.I. Pospelov took place.

The meeting was held in a “remote” format. There were 120 participants in total. Accepted as a member of MSDC 1 person.

Three clinical clinical observations are presented. The first of them is a case of giant-cell variant of annular granuloma with extensive skin lesions. Annular granuloma is a benign dermatosis of unclear etiology, prone to spontaneous resolution; it occurs as a reaction to ultraviolet radiation against the background of lymphoproliferative or autoimmune diseases, sarcoidosis, chronic lung diseases, prostate cancer. In the presented case, the clinical diagnosis was confirmed by histological examination.

The second presentation was devoted to livedoid vasculopathy with a tendency to thrombotic complications. This is a relatively rare disease that is excluded from the group of vasculitis due to one distinctive feature ― a pronounced tendency to thrombosis in the absence of indications of the primary nature of inflammation. In therapy, in addition to medications, the appointment of vitamins is mandatory.

The third observation concerned Merkel’s carcinoma, one of the relatively rare but extremely aggressive most malignant forms of skin cancer. With epithelial and neuroendocrine differentiation, which is superior to melanoma in terms of aggressiveness of the course and tendency to metastasis. Due to the rare occurrence of the tumor, diagnostic errors are frequent. Diagnosis requires histological and immunohistochemical examination. Any “inflamed atheroma” or synovial cyst that recurs after surgical treatment should be alarming.

Scientific reports were heard on the biological therapy of psoriasis, a chronic systemic immunoassociated disease of a multifactorial nature with a hereditary predisposition characterized by the formation of inflammatory papules and plaques, often with joint damage (arthropathy), accelerated proliferation of epidermocytes and a violation of their differentiation, an imbalance between pro-inflammatory and anti-inflammatory cytokines and chemokines. And the second scientific report contained information about modern approaches to the treatment of acantholytic pemphigus.