TLR-2 and TLR-4 expression levels as a prognostic index for recovery from chlamydiasis

Stanislav Stepanovich Bayrakova; Байракова Станислав Степанович; E A Voropaeva; Воропаева Е А; V A Aleshkin; Алешкин В А; S S Afanas'ev; Афанасьев С С; A V Karaulov; Караулов А В; L I Kafarskaya; Кафарская Л И; Yu V Nesvizhskiy; Несвижский Ю В; B A Efimov; Ефимов Б А; A N Shkoporov; Шкопоров А Н; O G Grechishnikova; Гречишникова О Г; S A Levakov; Леваков С А; V A Metel'skaya; Метельская В А; M S Afanas'ev; Афанасьев М С; E A Egorova; Егорова Е А; V V Slobodenyuk; Слободенюк В В; E V Fandeev; Фандеев Е В; A L Bairakova; Bairakova A L; Ye A Voropayeva; Voropayeva Ye A; V A Alyoshkin; Alyoshkin V A; S S Afanasyev; Afanasyev S S; A V Karaulov; Karaulov A V; L I Kafarskaya; Kafarskaya L I; Yu V Nesvizhsky; Nesvizhsky Yu V; B A Yefimov; Yefimov B A; A N Shkoporov; Shkoporov A N; O G Grechishnikova; Grechishnikova O G; S A Levakov; Levakov S A; V A Metelskaya; Metelskaya V A; M S Afanasyev; Afanasyev M S; Ye A Yegorova; Yegorova Ye A; V V Slobodenyuk; Slobodenyuk V V; Ye V Fandeyev; Fandeyev Ye V

doi:10.17816/EID40481

TLR-2 and TLR-4 expression levels as a prognostic index for recovery from chlamydiasis

作者: Bayrakova S.¹, Voropaeva E¹, Aleshkin V¹, Afanas'ev S¹, Karaulov A², Kafarskaya L³, Nesvizhskiy Y.², Efimov B³, Shkoporov A³, Grechishnikova O¹, Levakov S², Metel'skaya V¹, Afanas'ev M¹, Egorova E¹, Slobodenyuk V¹, Fandeev E¹, Bairakova A⁴, Voropayeva Y.⁴, Alyoshkin V⁴, Afanasyev S⁴, Karaulov A⁵, Kafarskaya L⁶, Nesvizhsky Y.⁵, Yefimov B⁶, Shkoporov A⁶, Grechishnikova O⁴, Levakov S⁵, Metelskaya V⁴, Afanasyev M⁴, Yegorova Y.⁴, Slobodenyuk V⁴, Fandeyev Y.⁴
隶属关系:
1. ФГУН Московский НИИ эпидемиологии и микробиологии им. Г. Н. Габричевского Роспотребнадзора
2. ГОУ ВПО Московская медицинская академия им. И. М. Сеченова
3. ГОУ ВПО Российский государственный медицинский университет
4. G. N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare
5. I. M. Sechenov Moscow Medical Academy
6. Russian State Medical University, Russian Agency for Health Care
期: 卷 15, 编号 4 (2010)
页面: 35-42
栏目: Articles
URL: https://journals.rcsi.science/1560-9529/article/view/40481
DOI: https://doi.org/10.17816/EID40481
ID: 40481

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详细

The authors studied an association between the expression of TLR-2 and TLR-4 on the epithelial surfaces of the urogenital tract and the clinical manifestations of female urogenital chlamydial infection. Clinical and laboratory studies were conducted in 41 patients with acute urogenital chlamydial infection, 29 patients with chronic urogenital chlamydial infection, 30 patients with a history of diagnosed urogenital chlamydiasis (the markers of these microorganisms had not been detected in the urogenital tract by any of the used studies for a year), and 32 healthy female donors (a control group). The levels of TLR-2 and TLR-4 can serve as criteria for evaluating the degree of chlamydial infection and the presence of an inflammatory process in patients. The eradication of the pathogen can be judged from the changes in the levels of TLR-2 and TLR-4 in some cases when the causative agent was not identified by laboratory tests before treatment and the diagnosis was established in a patient from the markers that were indirectly indicative of her chlamydial infection. The enhanced protective reaction in the focus of affliction is always accompanied by increased TLR-2 and TLR-4 activation. The low levels of TLR-2 and TLR-4 can indicate that the infectious process may become chronic.

关键词

urogenital chlamydiasis, cultural diagnosis, pathogen-associated molecular patterns, Toll-like receptors (TLR), nonmicrobial pathogens

参考

Интерфероновый статус, препараты интерферона в лечении и профилактике инфекционных заболеваний и реабилитации больных / Под ред. С. С. Афанасьева и др. - М., 2005.
Клиника, диагностика и лечение хламидийной инфекции (пособие для врачей) / Кудрявцева Л. В., Мисюрина О. Ю., Генерозов Э. В. и др. - М., 2001.
О совершенствовании контроля за заболеваниями, передаваемыми половым путем: Метод. рекомендации. - М., 1995.
Савичева А. М., Башмакова М. А. Урогенитальный хламидиоз у женщин и его последствия. - Н. Новгород, 1998.
Хламидийная инфекция в акушерстве и гинекологии (Диагностика, клиника, лечение): Метод. пособие / Савичева А. М., Башмакова М. А., Кошелева Н. Г. и др. - СПб., 2002.
Сидоренко М. Г. Статистика: Учеб. пособие. - М., 2007.
Юнкеров В. И., Григорьев С. Г. Математико-статистическая обработка данных медицинских исследований. 2-е изд. Изд. - СПб., 2005.
Якубович А. И., Корепанов А. Р. Урогенитальный хламидиоз. - Иркутск, 2007.
Beatty W. L., Byrne G. J., Morrison R. P. Repeated and persistent infection with Chlamydia and persistent infection with Chlamydia and development of chronic inflammation and didease // Trends Microbiol. - 1994. - Vol. 2. - P. 94-98.
Beatty W. L., Morrison R. P., Byrne G. L. Reactivation of persistent Chlamydia trachomatis infection in cell culture // Infect. and Immun. - 1995. - Vol. 63. - P. 199-205.
Darville T., O'Neil J. M., Andrews C. W. et al. Toll-like receptor-2, but not Toll-lile receptor-4, is essential for development of oviduct pathology in Chlamydial genital tract infection // J. Immunol. - 2003. - Vol. 171. - P. 6187-6197.
Medzhitov R., Preston-Hurlburt P., Janeway C. A. A human homologue of the Drosophila Toll proyein signals activation of adaptive immunity // Nature. - 1997. - Vol. 388, N 6440. - P. 323-327.
Pioli P. A., Amiel E., Schaefer T. M. et al. Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tract // Infect. and Immun. - 2004. - Vol. 73, N 1. - P. 5799-5806.
Rock F. L., Hardiman G., Timans J. C. et al. A family of human receptor structurially related to Drosophila Toll // Proc. Natl. Acad. Sci. USA. - 1998. - Vol. 95. - P. 588.
Sandor F., Buc M. Toll-like receptor III. Biological significance and impact for human medicine // Folia Biol. (Praha). - 2005. Vol. 51. - P. 198-203.
Shiraki R., Inoue N., Kawasaki S. et al. Expression of Toll-like receptors on human platelets // Thromb. Res. - 2004. - Vol. 113. - P. 379-385.

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TLR-2 and TLR-4 expression levels as a prognostic index for recovery from chlamydiasis

全文:

详细

关键词

作者简介

Stanislav Bayrakova

E Voropaeva

V Aleshkin

S Afanas'ev

A Karaulov

L Kafarskaya

Yu Nesvizhskiy

B Efimov

A Shkoporov

O Grechishnikova

S Levakov

V Metel'skaya

M Afanas'ev

E Egorova

V Slobodenyuk

E Fandeev

A Bairakova

Ye Voropayeva

V Alyoshkin

S Afanasyev

A Karaulov

L Kafarskaya

Yu Nesvizhsky

B Yefimov

A Shkoporov

O Grechishnikova

S Levakov

V Metelskaya

M Afanasyev

Ye Yegorova

V Slobodenyuk

Ye Fandeyev

参考