THE DETECTION OF IGG TO HUMAN HERPESVIRUS TYPE 7 IN CHILDREN


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Abstract

Background. There are no data on HHV-7 seroprevalence in Russia. Previously we detected HHV-7 DNA in plasma of 8-10% children with exanthem subitum and fever without rash. Aim. To perform the comparative study of the seroprevalence of HHV-7 and HHV-6 in children in Russia. Materials and methods. The pilot study included 116 children, aged from 10 days to 10 years. Serum samples were tested for IgG to HHV-7 and HHV-6 by indirect immunofluorescent assays and ELISA correspondingly. Results. The prevalence rate antibodies to HHV-7 was three times lower than for antibodies to HHV-6. There were only 18% of patients seropositive to HHV-7, whereas 50% of cases appeared to be seropositive to HHV-6. In infants younger 6 months the frequency of HHV-7 seropositivity amounted to 14.8%, which possibly was due to maternal antibodies. In babies aged from 7 months to 4 years, the HHV-7 seroprevalence was about 7-13%. In children older than 4 years the rate of seropositivity raised to 31%. Conclusion. We can conclude that in life the contact with HHV-7 occurs later than to HHV-6, predominantly after the age of four years. In children under 10 years, the seroprevalence to HHV-7 is lower than to HHV-6. The sample size of our study is too small to extrapolate on Russian population and other seroprevalence studies are needed.

About the authors

Mikhail A. Nikolskiy

I.P. Pavlov First State Medical University

Email: nicolm@inbox.ru
MD, PhD, pediatrician, assistant professor 6/8, Lva Tolstogo str., 197022, Saint Petersburg, Russia

L. B Kulyashova

Pasteur Institute of Epidemiology and Microbiology

14, Mira str., 197101, Saint Petersburg, Russia

A. V Zakrevskaya

Pasteur Institute of Epidemiology and Microbiology

14, Mira str., 197101, Saint Petersburg, Russia

D. A Lioznov

I.P. Pavlov First State Medical University; Pasteur Institute of Epidemiology and Microbiology

6/8, Lva Tolstogo str., 197022, Saint Petersburg, Russia; 14, Mira str., 197101, Saint Petersburg, Russia

T. A Kaptur

N.F. Filatov Children’s Municipal Clinical Hospital № 5

134, Bukharestskaya str., 192289, St. Petersburg, Russia

M. A Zolotova

N.F. Filatov Children’s Municipal Clinical Hospital № 5

134, Bukharestskaya str., 192289, St. Petersburg, Russia

References

  1. Frenkel N., Schirmer E., Wyatt L., Katsafanas G., Roffman E., Danovich R.M. et al. Isolation of a new herpesvirus from human CD4+ T cells. Proc. Natl. Acad. Sci. USA. 1990; Vol. 87: 748-52.
  2. Flamand L., Lautenschlager I., Krueger G. Ablashi D. Human Herpesviruses HHV-6A, HHV-6B, and HHV-7. Diagnosis and Clinical Management. Third edition 2014.
  3. Ihira M., Yoshikawa T., Ohashi M., Enomono Y., Akimoto S., Suga S. et al. Variation of human herpesvirus 7 shedding in saliva. J. Infect. Dis. 2003; Vol. 188: 1352-4.
  4. Fujisaki H., Tanaka-Taya K., Tanabe H., Hara T., Miyoshi H., Okada S. et al. Detection of human herpesvirus 7 (HHV-7) DNA in breast milk by polymerase chain reaction and prevalence of HHV- 7 antibody in breast-fed and bottle-fed children. J. Med. Virol. 1998. Vol. 56: 275-9.
  5. Takahashi Y., Yamada M., Nakamura J. Sukazaki T., Padilla J., Kitamura T. et al. Transmission of human herpesvirus 7 through multigenerational families in the same household. Pediatr. Infect. Dis. J. 1997; Vol. 16: 975-8.
  6. Hall С.B., Caserta M.T., Schnabel K.C., McDermott M.P., Lofthus G.K. Characteristics and Acquisition of Human Herpesvirus (HHV)-7 Infections in Relation to Infection with HHV-6. The Journal of Infectious Diseases. Vol. 193, Issue 8: 1063-9
  7. Bustos D, Biganzoli P, Carricart SE, Ferreyra L, Nates SV, Pavan JV. Loss of maternally-derived human herpesvirus-7 immunity and natural infection in Argentinian infants. Int J Infect Dis. 2006 Sep;10(5): 354-7
  8. Hall C.B., Caserta M.T., Schnabel K.C., Boettrich C., McDermott M.P., Lofthus G.K. et al. Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7). J. Pediatr. 2004; Vol. 45(4): 472-7.
  9. Prusty BK, Gulve N, Rasa S, Murovska M, Hernandez PC, Ablashi DV. Possible chromosomal and germline integration of human herpesvirus 7. J Gen Virol. 2017 Feb; 98(2): 266-74.
  10. Schwartz KL, Richardson SE, Ward KN. Delayed primary HHV-7 infection and neurologic disease. Pediatrics. 2014 Jun; 133(6): 1541-7.
  11. Holden SR, Vas AL. Severe encephalitis in a haematopoietic stem cell transplant recipient caused by reactivation of human herpesvirus 6 and 7. J Clin Virol. 2007; 40: 245-7.
  12. Жебрун А.Б., Кулешова Л.Б., Закревская А.В., Сварваль А.В., Ермоленко К.Д. Инфицированность детей вирусами герпеса 1, 2, 4, 5 и 8 типов в Санкт-Петербурге. Здоровье - основа человеческого потенциала: проблемы и пути их решения. 2012; 7(2): 755-6.
  13. Прокопенко Е.И., Щербакова Е.О., Ватазин А.В., Русанова Е.В., Степанов В.А., Панкратенко Т.Е. и др. Инфицированность герпетическими вирусами и пневмоцистами сотрудников центра трансплантации и диализа. Альманах клинической медицины. 2012; 27: 39-46.
  14. Никольский М.А., Радыш М.В. Роль вирусов герпеса человека 6 и 7-го типов в возникновении фебрильных судорог у детей. Вопросы диагностики в педиатрии. 2012; 4(4): 46-8.
  15. Никольский М.А., Вязовая А.А., Нарвская О.В. Инфекция, обусловленная вирусом герпеса человека 7 типа у детей. Детские инфекции. 2012; 11(4): 36-9.

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