Immunopathogenetic features of bacterial purulent meningitides


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Abstract

The aim of the study. Comparative assessment of the state of cells of the immune system in patients with purulent bacterial meningitides caused by N.meningitidis and S.pneumoniae . Materials and methods. By the method offlow cytofluorometry there were tested blood and cerebrospinal fluid of 65 patients with bacterial purulent meningitis, with the meningococcal (38 people) and pneumococcal (27 people) nature of the disease. Results. There were revealed general consistencies of the immune response to CNS infection with meningococcus andpneumococcus: the fall of the number of CD16+ CD56+(NK) and the gain in the number of CD19+ cells in the blood, an increase in the absolute number of T lymphocytes, especially, CD3+ CD8+ and NK. In pneumococcal meningitis there was noted the more pronounced upsurge in the absolute number of the NKT (CD3+CD56+) and B-lymphocytes in the blood whereas in cerebrospinal fluid - the more pronounced upturn in the absolute number of NKT that testified to the severe course of the disease. Conclusion. As a result of performed studies there was identified a series of consistencies for the development of the immune response in bacterial purulent meningitides of meningococcal and pneumococcal etiology, which show the high informativeness of the study of immunograms of cerebrospinal fluid in these diseases as compared with blood. In the latter case, immunological studies may contribute not only to the identification of general consistencies of the development of the immune response in bacterial meningitis, but also serve as a basis for the differentiation of the impact of meningococcal and pneumococcal infection on immunocompetent cells, as well as to reflect the severity of the course of the disease, affecting the nature of the therapy.

About the authors

I. P Balmasova

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

Email: iri.balm@mail.ru
доктор мед. наук, проф., зав. лаб. патогенеза и методов лечения инфекционных заболеваний Научно-исследовательского медико-стоматологического института 20, bld. 1, Delegatskaya Str., Moscow, Russian Federation, 127473

Yu. Ya Vengerov

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

доктор мед. наук, профессор, проф., каф. инфекционных болезней и эпидемиологии 20, bld. 1, Delegatskaya Str., Moscow, Russian Federation, 127473

S. E Razdobarina

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

аспирант каф. инфекционных болезней и эпидемиологии 20, bld. 1, Delegatskaya Str., Moscow, Russian Federation, 127473

M. V Nagibina

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

Email: infektor03@gmail.com
канд. мед. наук, доцент каф. инфекционных болезней и эпидемиологии 20, bld. 1, Delegatskaya Str., Moscow, Russian Federation, 127473

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