THE CLINICAL SIGNIFICANCE OF DETECTION OF RNA IN PATIENTS WITH CHRONIC VIRAL HEPATITES


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Abstract

593 patients with chronic viral hepatitis were tested for HGV-RNA and TTV DNA of. HGV-RNA detected in 3 times less than TTV DNA - in 13.6% and 46.64%, respectively. A comparative evaluation of clinical and biochemical parameters in patients with coinfection HCV/HGV and HCV monoinfection revealed significant differences in the average level of activity of ALT and the rate of increased ALT, which were higher in Hepatitis C patients with HGV RNA in the blood. There was no influence of HGV infection on other clinical and biochemical parameters and levels of fibrosis in groups of patients with HCV monoinfected and co-infection HCV/ HGV. The presence of HGV RNA in blood Hepatitis C patients did not affect the effectiveness of AVT. 30 patients with Hepatitis C and Hepatitis B with HGV RNA in blood were examined three times on the background of the AVT (before, during and after treatment). In 23 out of 30 patients (76.6%) a disappearance of HGV RNA in the blood took place during AVT, but after treatment in 17 patients (53.3%) HGV RNA replication is resumed, i. e. suppression of replication on the background of AVT was temporary. In individuals with HGV monoinfection (n 12) clinical symptoms were poor, in half of the patients in this group of young and middle age the increase in cholesterol levels was noticed, as well as the sonographic signs of fatty liver.

About the authors

N. I. Gromova

Federal State Institution Polyclinic №1 of the Office of Presidential Affairs of Russia

I. V. Gordeychuk

Federal State Budget-Financed Institution Chumakov Institute ofpoliomielitis and viral encephalitides ofRAMS, Institut poliomielita

канд. мед. наук, мл. науч. сотр. лаб. этиологии, диагностики, эпидемиологии и профилактики вирусных гепатитов Института полиомиелита и вирусных энцефалитов им. М. П. Чумакова РАМН

K. K. Kyuregyan

Federal State Budget-Financed Institution Chumakov Institute ofpoliomielitis and viral encephalitides ofRAMS, Institut poliomielita

канд. биол. наук, зав. лаб. этиологии, диагностики, эпидемиологии и профилактики вирусных гепатитов Института полиомиелита и вирусных энцефалитов им. М. П. Чумакова РАМН

L. U. Ilchenko

Federal State Budget-Financed Institution Chumakov Institute ofpoliomielitis and viral encephalitides ofRAMS, Institut poliomielita

д-р мед. наук, проф., зав. отд-нием вирусных гепатитов Института полиомиелита и вирусных энцефалитов им. М. П. Чумакова РАМН

M. I. Mikhailov

Federal State Budget-Financed Institution Chumakov Institute ofpoliomielitis and viral encephalitides ofRAMS, Institut poliomielita

д-р мед. наук, проф., дир. Института полиомиелита и вирусных энцефалитов им. М. П. Чумакова РАМН

References

  1. Балаян М. С., Полещук В. Ф. Вирусные гепатиты у приматов: экспериментальное заражение и естественное течение // Вирус. гепатиты. - 1998. - № 3. - С. 3-12.
  2. Громова Н. И., Кюрегян К. К., Михайлов М. И. и др. Влияние инфицирования вирусом ТТ на течение и эффективность лечения хронических вирусных гепатитов // Инф. бол. - 2011. - № 1. - С. 14-18.
  3. Дмитриев П. Н., Кюрегян К. К., Михайлов М. И. и др. GBVC-инфекция у ВИЧ-инфицированных пациентов в Российской Федерации // Вопр. вирусол. - 2010. - № 1. - С. 23-26.
  4. Ильченко Л. Ю., Шарафанова Т. И., Шепелева С. Д., Серова Т. И. Антитела к вирусу гепатита G у пациентов с хроническими заболеваниями печени // Гепатология. - 2003. - № 5. - С. 4-6.
  5. Ильченко Л. Ю., Карлович Т. И. Клинико-вирусологические особенности микст-гепатитов // Сборник трудов ИПВЭ им. М. П. Чумакова РАМН. - М., 2007. - С. 297-302.
  6. Логинов А. С., Львов Д. К., Шарафанова Т. И. и др. Выявление вируса гепатита G при хронических заболеваниях печени // Рос. журн. гастроэнтерол. - 1999. - № 1. - С. 23-31.
  7. Логинов А. С., Шарафанова Т. И., Решетняк В. И. и др. HGV и TTV-новые вирусы гепатитов // Тер. арх. - 2000. - Т. 72, № 2. - С. 9-13.
  8. Михайлов М. И. Гепатит G: проблемы изучения // Вирус. гепатиты. - 1997. - № 1. - С. 3-11.
  9. Alter H. J. The cloning and clinical implications of HGV and HG-BV-C // N. Engl. J. Med. - 1996. - Vol. 334. - P. 1536-1537.
  10. Garcia F. Jr., Garcia F., Roldan C. et al. Detection of HCV and GBV-CHGV RNA in peripheral blood mononuclear cells of patients with chronic type C hepatitis // Microbiol. - 2000. - Vol. 103. - P. 7-15.
  11. Handa A., Brown K. E. GB virus C/hepatitis G virus replicates in human haematopoietic cells and vascular endothelial cells // J. Gen. Virol. - 2000. - Vol. 81. - P. 2461-2469.
  12. Hwang S. J., Lu R. H., Chan C. Y. et al. Detection of antibodies to E2-protein of GB virus-C/hepatitis G virus in patients with acute posttransfusion hepatitis // J. Med. Virol. - 1999. - Vol. 57. - P. 85-89.
  13. Kao J. H., Chen W., Chen P. J. et al. Liver and peripheral blood mononuclear cells are not major sites for GB virus-C/hepatitis G virus replication // Arch. Virol. - 1999. - Vol. 144. - P. 2173-2183.
  14. Kudo T., Morishima T., Shibata M. Hepatitis G infection // N. Engl. J. Med. - 1997. - Vol. 337. - P. 276-277.
  15. Lefrere J. J., Sender A., Mercier B. et al. High rate of GB virus type C/HGV transmission from mother to infant: possible implications for the prevalence of infection in blood donors // Transfusion. - 2000. -Vol. 40. - P. 602-607.
  16. Linnen J., Wages J. Jr., Zhang-Keck Z. Y. et al. Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent // Science. - 1996. - Vol. 271. - P. 505-508.
  17. Ohto H., Ujiie N., Sato A. et al. Motherto-infant transmission of GB virus type C/HGV // Transfusion. - 2000. - Vol. 40. - P. 725-730.
  18. Orito E., Mizokami M., Yasuda K. et al. Interferon-alpha therapy in patients dually infected with hepatitis C virus and GB virus C/ hepatitis G virus - virological response of HGV and pretreatment HGV viremia level // J. Hepatol. - 1997. - Vol. 27. - P. 603-612.
  19. Palomba E., Bairo A., Tovo P. A. High rate of maternal-infant transmission of hepatitis G virus in HIV-1 and hepatitis C virus-infected women // Act. Paediatr. - 1999. - Vol. 88. - P. 1392-1395.
  20. Pessoa M. G., Terrault N. A., Detmer J. et al. Quantitation of hepatitis G and C viruses in the liver: evidence that hepatitis G virus is not hepatotropic // Hepatology. - 1998. - Vol. 27. - P. 877-880.
  21. Saiz J. C., Ampurdanes S., Olmedo E. et al. Hepatitis G virus infectionin chronic hepatitis C: frequency, features and response to interferon therapy // J. Hepatol. - 1997. - Vol. 26. - P. 787-793.
  22. Simons J. N., Pilot-Matias T. J., Leary T. P. et al. Identification of two flavivirus-like genomes in the GB hepatitis agent // Proc. Nat. Acad. Sci. USA. - 1995. - Vol. 92. - P. 3401-3405.
  23. Stark K., Doering C. D., Bienzle U. et al. Risk and clearance of GB virus C/hepatitis G virus infection in homosexual men: A longitudinal study // J. Med. Virol. - 1999. - Vol. 59. - P. 303-306.
  24. Tanaka E., Tacke M., Kobayashi M. et al. Past and present hepatitis G virus infections in areas where hepatitis C is highly endemic and those where it is not endemic // J. Clin. Microbiol. - 1998. - Vol. 36. - P. 110-114.
  25. Thomas D. L., Vlahov D., Alter H. J. et al. Association of antibody to GBV (hepatitis G virus) with viral clearance and protection from reinfection // J. Infect. Dis. - 1998. - Vol. 177. - P. 539-542.
  26. Yang J. F., Dai C. Y., Chuang W. L. et al. Prevalence and clinical significance of HGV/GBV-C infection in patients with chronic hepatitis B or C // Jpn. J. Infect. Dis. - 2006. - Vol. 59. - P. 25-30.
  27. Yeo A. E., Matsumoto A., Shih J. W. et al. Prevalence of hepatitis G virus in patients with hemophilia and their steady female sexual partners // Sex. Transm. Dis. - 2000. - Vol. 27. - P. 178-182.

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