Meningococcal carriage: Riddles and clues


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Abstract

The paper reviews the current views of healthy carriage formation, such as colonization of the entry of infection. It presents an update of the genetically heterogeneity of a meningococcal population and differences between the strains isolated from carriers and patients. The process of mucosal colonization and biofilm formation are described. Data on an immune response in bacterial carriage are pooled and it is concluded that carriage gives rise to a systemic immune response that protects from a generalized disease caused by the serogroup that is homologous to strain carriage. However, the occurring local (mucous) immune response is inadequately tense and fails to protect from recolonization. When mass immunization can affect the spread of carriage due to elimination of the powerful infection sources - patients with generalized forms is discussed.

About the authors

Natal'ya Nikolaevna Kostyukova

ГУ НИИ эпидемиологии и микробиологии им. Н. Ф. Гамалеи РАМН

Email: nearmedic_uc@mail.ru
д-р мед. наук, проф., вед. научный сотр. ГУ НИИ эпидемиологии и микробиологии им. Н. Ф. Гамалеи РАМН; ГУ НИИ эпидемиологии и микробиологии им. Н. Ф. Гамалеи РАМН

V A Bekhalo

ГУ НИИ эпидемиологии и микробиологии им. Н. Ф. Гамалеи РАМН

ГУ НИИ эпидемиологии и микробиологии им. Н. Ф. Гамалеи РАМН

N N Kostyukova

N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences

N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences

V A Bekhalo

N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences

N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences

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