电邮这篇文章 Solvent-Free FeCl3-Assisted Electrophilic Fluorine-Catalyzed Knoevenagel Condensation to Yield α,β-Unsaturated Dicarbonyl Compounds and Coumarins
- 作者: Yang L.1,2, Zhu J.1,2,3, Xie F.1,2,3, Peng X.1,2, Lin B.1,2, Liu Y.1,2,3, Cheng M.1,2
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隶属关系:
- Key Laboratory of Structure-Based Drug Design and Discovery
- Institute of Drug Research in Medicine Capital of China
- Wuya College of Innovation
- 期: 卷 55, 编号 7 (2019)
- 页面: 1053-1060
- 栏目: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/220981
- DOI: https://doi.org/10.1134/S1070428019070236
- ID: 220981
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详细
A highly environmentally friendly procedure was developed for the Knoevenagel condensation of aromatic aldehydes with diethyl malonate in the presence of FeCl3 and N-fluorobenzenesulfonimide as a source of electrophilic fluorine under solvent-free conditions. The scope of the reaction was explored using commercially available substrates. The reaction with substituted salicylaldehydes afforded the corresponding coumarin derivatives which attract interest due to their potential medicinal importance.
作者简介
Lu Yang
Key Laboratory of Structure-Based Drug Design and Discovery; Institute of Drug Research in Medicine Capital of China
Email: mscheng@syphu.edu.cn
中国, Shenyang; Benxi
Jiang Zhu
Key Laboratory of Structure-Based Drug Design and Discovery; Institute of Drug Research in Medicine Capital of China; Wuya College of Innovation
Email: mscheng@syphu.edu.cn
中国, Shenyang; Benxi; Shenyang
Fukai Xie
Key Laboratory of Structure-Based Drug Design and Discovery; Institute of Drug Research in Medicine Capital of China; Wuya College of Innovation
Email: mscheng@syphu.edu.cn
中国, Shenyang; Benxi; Shenyang
Xiaoshi Peng
Key Laboratory of Structure-Based Drug Design and Discovery; Institute of Drug Research in Medicine Capital of China
Email: mscheng@syphu.edu.cn
中国, Shenyang; Benxi
Bin Lin
Key Laboratory of Structure-Based Drug Design and Discovery; Institute of Drug Research in Medicine Capital of China
Email: mscheng@syphu.edu.cn
中国, Shenyang; Benxi
Yongxiang Liu
Key Laboratory of Structure-Based Drug Design and Discovery; Institute of Drug Research in Medicine Capital of China; Wuya College of Innovation
编辑信件的主要联系方式.
Email: yongxiang.liu@syphu.edu.cn
中国, Shenyang; Benxi; Shenyang
Maosheng Cheng
Key Laboratory of Structure-Based Drug Design and Discovery; Institute of Drug Research in Medicine Capital of China
编辑信件的主要联系方式.
Email: mscheng@syphu.edu.cn
中国, Shenyang; Benxi
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