电邮这篇文章 A Convenient Synthesis of N2-Alkylated Guanines
- 作者: Zhu H.T.1, Qin L.Y.1, Liu T.1, Luo Y.1
-
隶属关系:
- Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
- 期: 卷 55, 编号 6 (2019)
- 页面: 874-878
- 栏目: Review
- URL: https://journals.rcsi.science/1070-4280/article/view/220788
- DOI: https://doi.org/10.1134/S1070428019060198
- ID: 220788
如何引用文章
开放存取
##reader.subscriptionAccessGranted##
订阅存取
详细
An improved three-step synthesis of N2-alkylated guanines has been developed starting from N2-Boc-protected 2-amino-6-chloropurine which was treated with Boc2O, and the resulting doubly N2,9-protected derivative was subjected to N2-alkylation with alkyl halides, followed by hydrolysis. The advantages of this procedure include short reaction steps, simple operations, and good yields.
作者简介
H. Zhu
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Email: yluo@chem.ecnu.edu.cn
中国, Shanghai
L. Qin
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Email: yluo@chem.ecnu.edu.cn
中国, Shanghai
T. Liu
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
Email: yluo@chem.ecnu.edu.cn
中国, Shanghai
Y. Luo
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
编辑信件的主要联系方式.
Email: yluo@chem.ecnu.edu.cn
中国, Shanghai
补充文件
