Synthesis and Biological Activity of Alkane-1,1-diylbis(phosphonates) of Diterpenoid Isosteviol
- 作者: Strobykina I.Y.1, Nemtarev A.V.1, Garifullin B.F.1, Voloshina A.D.1, Sapunova A.S.1, Kataev V.E.1
-
隶属关系:
- Arbuzov Institute of Organic and Physical Chemistry
- 期: 卷 55, 编号 1 (2019)
- 页面: 17-24
- 栏目: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/219695
- DOI: https://doi.org/10.1134/S1070428019010044
- ID: 219695
如何引用文章
详细
Isosteviol reacted with α,ω-dibromoalkanes to give 19-(ω-bromoahkyl) esters which were treated with tetraethyl methylenebis(phosphonate) to obtain bis(phosphonates) conjugated to the deterpenoid skeleton through a polymethylene spacer. The bis(phosphonates) were converted to the corresponding bis(phosphonic acids) by transformation to trimethylsilyl esters and subsequent methanolysis. One of the synthesized compounds showed a high antimicrobial activity (MIC 3.9 µg/mL) against S. aureus and a high cytotoxicity (IC50 15–18 µM) toward M-HeLa and MCF-7 human cancer cell lines.
作者简介
I. Strobykina
Arbuzov Institute of Organic and Physical Chemistry
Email: kataev@iopc.ru
俄罗斯联邦, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
A. Nemtarev
Arbuzov Institute of Organic and Physical Chemistry
Email: kataev@iopc.ru
俄罗斯联邦, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
B. Garifullin
Arbuzov Institute of Organic and Physical Chemistry
Email: kataev@iopc.ru
俄罗斯联邦, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
A. Voloshina
Arbuzov Institute of Organic and Physical Chemistry
Email: kataev@iopc.ru
俄罗斯联邦, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
A. Sapunova
Arbuzov Institute of Organic and Physical Chemistry
Email: kataev@iopc.ru
俄罗斯联邦, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
V. Kataev
Arbuzov Institute of Organic and Physical Chemistry
编辑信件的主要联系方式.
Email: kataev@iopc.ru
俄罗斯联邦, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
补充文件
