Synthesis of β-(2,2-diethoxyethyl)-substituted (allyl)tributylstannane and its application to asymmetric allylation


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Аннотация

Previously unknown tributyl-[(2-methylidene-4,4-diethoxy)butyl]stannane was prepared from diethyl acetal of 3-(bromomethyl)but-3-enal and was brought subsequently into a catalytic asymmetric Keck allylation of butanal in order to obtain optically active homoallylic alcohol. The use of activating additives [B(OBu)3 and CF3COOH] favors the process proceeding with high yields and enantioselectivity. An approach was suggested to the synthesis of С14–С21 fragments of amphidinolide Т applying tributyl[(2-methylidene-4,4-diethoxy)butyl]stannane in the key stage of building up the carbon scaffold.

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Авторлар туралы

V. Masyuk

Belarus State University

Email: i.mineyeva@yandex.ru
Белоруссия, pr. Nezavisimosti 4, Minsk, 220030

I. Mineeva

Belarus State University

Хат алмасуға жауапты Автор.
Email: i.mineyeva@yandex.ru
Белоруссия, pr. Nezavisimosti 4, Minsk, 220030

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