Aminomethylation of substituted pyrroles and 4,5,6,7-tetrahydroindoles with biogenic cyclic amines
- Авторлар: Markova M.V.1, Sobenina L.N.1, Ushakov I.A.1, Ivanov A.V.1, Trofimov B.A.1
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Мекемелер:
- Favorskii Irkutsk Institute of Chemistry, Siberian Branch
- Шығарылым: Том 53, № 2 (2017)
- Беттер: 184-191
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/215740
- DOI: https://doi.org/10.1134/S1070428017020075
- ID: 215740
Дәйексөз келтіру
Аннотация
Aminomethylation of 2-methyl(aryl)-, 2-aryl-3-alkylpyrroles, 4,5,6,7-tetrahydroindole and its 1-vinyl- and 1-benzyl-substituted derivatives with a mixture of 5% water-ethanol solution of formaldehyde and cyclic amine (pyrrolidine, piperazine, and morpholine) without catalyst at room temperature leads to the formation of the corresponding 2-aminomethylpyrroles and 2-aminomethyl-4,5,6,7-tetrahydroindoles in up to 92% yields. In reaction of 1-vinyl-4,5,6,7-tetrahydroindole with formaldehyde water solution and piperazine in a 60% yield 1,4-bis(1-vinyl-4,5,6,7-tetrahydroindol-2-yl)piperazine was obtained, a promising bifunctional monomer and a building block for the synthesis of new indole derivatives, in particular, of biologically active polymers. In the reaction of 2-methylpyrrole and 4,5,6,7-tetrahydroindole with formaldehyde and morpholine along with the С2-aminomethylation the 1-hydroxymethylation of the pyrrole ring was observed.
Авторлар туралы
M. Markova
Favorskii Irkutsk Institute of Chemistry, Siberian Branch
Email: boris_trofimov@irioch.irk.ru
Ресей, ul. Favorskogo 1, Irkutsk, 664033
L. Sobenina
Favorskii Irkutsk Institute of Chemistry, Siberian Branch
Email: boris_trofimov@irioch.irk.ru
Ресей, ul. Favorskogo 1, Irkutsk, 664033
I. Ushakov
Favorskii Irkutsk Institute of Chemistry, Siberian Branch
Email: boris_trofimov@irioch.irk.ru
Ресей, ul. Favorskogo 1, Irkutsk, 664033
A. Ivanov
Favorskii Irkutsk Institute of Chemistry, Siberian Branch
Email: boris_trofimov@irioch.irk.ru
Ресей, ul. Favorskogo 1, Irkutsk, 664033
B. Trofimov
Favorskii Irkutsk Institute of Chemistry, Siberian Branch
Хат алмасуға жауапты Автор.
Email: boris_trofimov@irioch.irk.ru
Ресей, ul. Favorskogo 1, Irkutsk, 664033
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